Dr. Reddy's Analytical Scientist Interview Questions, Process, and Tips

Q1. What is the ESI and APCI difference? What is the way of development of method for Impurities??
Ans. 
ESI and APCI are ionization techniques used in mass spectrometry. Method development for impurities involves identification, quantification, and validation.
• ESI (Electrospray Ionization) and APCI (Atmospheric Pressure Chemical Ionization) are ionization techniques used in mass spectrometry.

• ESI is suitable for polar and ionic compounds, while APCI is suitable for nonpolar and less polar compounds.

• ESI involves the formati...read more
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Q1. Current approaches on nitrosamine impurities
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Current approaches on nitrosamine impurities
• Analytical techniques such as LC-MS and GC-MS are commonly used to detect and quantify nitrosamine impurities in pharmaceuticals

• Regulatory agencies have set limits on the acceptable levels of nitrosamine impurities in drugs

• Manufacturers are required to conduct risk assessments and implement control measures to prevent nitrosamine contamination

• Some common approaches to mitigat...read more
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Q2. Limits for nitrosamine impurities and regulatory aspects
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Q1. Mass spectrometer - AB Sciex
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Q2. Quadrapoles functioning
Ans. 
Quadrapoles are used in mass spectrometry to filter ions based on their mass-to-charge ratio.
• Quadrapoles use radio frequency and direct current voltages to selectively filter ions.

• They are composed of four parallel rods that create a quadrupole electric field.

• Ions with a specific mass-to-charge ratio will oscillate within the field and pass through the filter.

• Quadrapoles are commonly used in tandem mass spectrometry fo
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Q3. Q trap system in quadrapoles
Ans. 
Q trap system is a type of mass spectrometer that uses triple quadrupole technology with an added linear ion trap for enhanced sensitivity and selectivity.
• Q trap system is used for targeted quantification and identification of small molecules in complex matrices.

• It combines the benefits of triple quadrupole technology with an added linear ion trap for enhanced sensitivity and selectivity.

• It allows for multiple reaction...read more
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Q1. Salary structure and general communication
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Q1. Analytical Method validation
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Q2. Analytical Method transfer
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Q3. Forced Degradation
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Q4. Related substances criteria
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Q1. Why you want to work here?
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Q2. Why you want to leave previous company?
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As per resume,
Technical discussion

Q1. Salary , policy
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