Analytical Chemist Interview Questions and Answers

Different types of chemical solution preparation include standard solutions, volumetric solutions, buffer solutions, and reagent solutions.

• Standard solutions are prepared by accurately weighing a known amount of a pure substance and dissolving it in a solvent.

• Volumetric solutions are prepared by measuring a known volume of a concentrated solution and diluting it to a desired concentration.

• Buffer solutions are prepared by mixing a weak acid and its conjugate base or a weak bas...read more

Q.C. testing parameters are specific criteria used to assess the quality of analytical results.

• Q.C. testing parameters are used to ensure the accuracy, precision, and reliability of analytical measurements.

• These parameters may include limits for acceptable levels of impurities, precision of measurements, accuracy of calibration standards, etc.

• Examples of Q.C. testing parameters include limit of detection, limit of quantitation, linearity, repeatability, reproducibility, etc.

I have 5 years of experience in the pharmaceutical industry.

• 5 years of experience in pharmaceutical industry

• Experience includes analytical testing, method development, and validation

• Worked with various analytical instruments such as HPLC, GC, and spectroscopy

• Familiar with regulatory requirements for pharmaceutical analysis

Instruments used in pharma include spectrophotometers, chromatographs, mass spectrometers, and pH meters.

• Spectrophotometers are used to measure the amount of light absorbed by a sample.

• Chromatographs separate and analyze components in a mixture.

• Mass spectrometers identify and quantify compounds based on their mass-to-charge ratio.

• pH meters measure the acidity or alkalinity of a solution.

SOP stands for Standard Operating Procedure, a set of step-by-step instructions to carry out routine operations.

• SOP is a detailed document that outlines the steps to be followed in a particular process or operation.

• It ensures consistency, quality, and safety in performing tasks.

• SOPs are commonly used in various industries such as pharmaceuticals, food production, and manufacturing.

• For example, an SOP for laboratory testing would include instructions on sample preparation, ana...read more

Reverse phase HPLC is a chromatographic technique where the stationary phase is non-polar and the mobile phase is polar.

• Stationary phase is non-polar, such as C18 bonded silica

• Mobile phase is polar, such as water/acetonitrile

• Analytes are separated based on their hydrophobicity

• Commonly used in pharmaceutical and environmental analysis