What is the ESI and APCI difference? What is the way of development of method for Impurities??

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ESI and APCI are ionization techniques used in mass spectrometry. Method development for impurities involves identification, quantification, and validation.

ESI (Electrospray Ionization) and APCI (Atmospheric Pressure Chemical Ionization) are ionization techniques used in mass spectrometry.
ESI is suitable for polar and ionic compounds, while APCI is suitable for nonpolar and less polar compounds.
ESI involves the formation of ions by the interaction of a sample with charged droplets, while APCI involves the formation of ions through chemical reactions in the gas phase.
Method development for impurities involves identification, quantification, and validation.
Identification of impurities can be done using techniques like HPLC, GC, or LC-MS.
Quantification of impurities can be done using calibration curves or internal standards.
Validation of the method involves assessing parameters like accuracy, precision, linearity, and robustness.

What is the ESI and APCI difference? What is the way of development of method for Impurities??

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