10+ Senior Scientist Interview Questions and Answers

Measures involved in process development of an API include optimization of synthetic route, selection of raw materials, purification techniques, and analytical method development.

• Optimization of synthetic route to improve yield and reduce impurities

• Selection of high-quality raw materials to ensure consistency and purity of the final product

• Development of purification techniques such as crystallization, distillation, or chromatography

• Analytical method development for testing t...read more

Yes, I have experience working with tricky dosage forms such as extended-release tablets and transdermal patches.

• Extended-release tablets require precise formulation to ensure controlled release of medication over an extended period of time.

• Transdermal patches involve designing a delivery system that allows for consistent absorption of medication through the skin.

• Other tricky dosage forms may include multiparticulate systems, liposomal formulations, and inhalation powders.

• Exa...read more

Single quadrupole and triple quadrupole differ in the number of quadrupole mass analyzers used in the instrument.

• Single quadrupole uses one quadrupole mass analyzer, while triple quadrupole uses three.

• Single quadrupole is used for qualitative analysis, while triple quadrupole is used for quantitative analysis.

• Triple quadrupole offers better sensitivity and selectivity compared to single quadrupole.

• Triple quadrupole allows for multiple reaction monitoring (MRM) experiments.

• Tri...read more

Various technologies have been used in the past for product development.

• CAD/CAM software for designing and manufacturing

• Prototyping technologies like 3D printing

• Simulation software for testing and analysis

• Data analysis tools for market research

• Collaboration platforms for team communication

• Automation and robotics for manufacturing processes

Method validation ensures accuracy, precision, and reliability of analytical results.

• To ensure that the method is suitable for its intended use

• To ensure that the method is accurate, precise, and reliable

• To comply with regulatory requirements

• To minimize the risk of producing incorrect results

• To ensure consistency in results over time and across different laboratories

• Examples: validation of analytical methods used in pharmaceuticals, food testing, environmental monitoring, etc.

Protein purification involves several steps including cell lysis, separation, and purification using chromatography.

• The protein source is harvested and the cells are lysed to release the protein.

• The protein is separated from other cellular components using techniques such as centrifugation or filtration.

• The protein is purified using chromatography, which separates the protein based on its physical and chemical properties.

• Different types of chromatography can be used, such as ...read more

IPC stands for Inter-Process Communication. It is a mechanism that allows processes to communicate and synchronize with each other.

• IPC allows processes to share data and communicate with each other

• There are different types of IPC mechanisms such as pipes, message queues, shared memory, and sockets

• Working principal involves sending and receiving messages between processes

• Example: Using pipes to communicate between a parent process and a child process

ICH guidelines are a set of internationally recognized standards for the development, registration, and post-approval of pharmaceutical products.

• ICH stands for International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use

• ICH guidelines provide recommendations on various aspects of drug development, including quality, safety, efficacy, and multidisciplinary topics

• Examples of ICH guidelines include Q1-Q14 guidelines, which cover topics such...read more

AEX stands for Amsterdam Exchange, a stock exchange in the Netherlands.

• AEX is a stock market index composed of the 25 most actively traded Dutch companies on the Amsterdam Exchange.

• It is often used as a benchmark for the Dutch stock market.

• Examples of companies included in the AEX index are Royal Dutch Shell, ASML, and Unilever.

AEX stands for Average Execution Time, a metric used to measure the average time taken to execute a process or task.

• AEX is calculated by summing up the total execution time of a process and dividing it by the number of executions.

• For example, if a process takes 10 seconds to execute and it is run 5 times, the AEX would be 10/5 = 2 seconds.

UV spectroscopy is a technique that uses ultraviolet light to measure the absorption, transmission, and emission of molecules.

• UV spectroscopy involves the use of ultraviolet light in the range of 190-400 nm.

• It is commonly used to analyze the electronic transitions in organic molecules.

• UV spectroscopy can provide information about the structure, purity, and concentration of a sample.

• The Beer-Lambert Law is often used in UV spectroscopy to relate absorbance to concentration.

• UV ...read more