Senior Scientist

10+ Senior Scientist Interview Questions and Answers

Updated 13 Dec 2024

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Q1. What are the measures involved in the process development of an Active Pharmaceutical Ingredient (API)?

Q2. Difference in single qudrapole and triple qudrapole

Ans.

Single quadrupole and triple quadrupole differ in the number of quadrupole mass analyzers used in the instrument.

  • Single quadrupole uses one quadrupole mass analyzer, while triple quadrupole uses three.

  • Single quadrupole is used for qualitative analysis, while triple quadrupole is used for quantitative analysis.

  • Triple quadrupole offers better sensitivity and selectivity compared to single quadrupole.

  • Triple quadrupole allows for multiple reaction monitoring (MRM) experiments.

  • Tri...read more

Senior Scientist Interview Questions and Answers for Freshers

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Q3. Technologies which were used during product development in the past

Ans.

Various technologies have been used in the past for product development.

  • CAD/CAM software for designing and manufacturing

  • Prototyping technologies like 3D printing

  • Simulation software for testing and analysis

  • Data analysis tools for market research

  • Collaboration platforms for team communication

  • Automation and robotics for manufacturing processes

Q4. Why we need to method validation

Ans.

Method validation ensures accuracy, precision, and reliability of analytical results.

  • To ensure that the method is suitable for its intended use

  • To ensure that the method is accurate, precise, and reliable

  • To comply with regulatory requirements

  • To minimize the risk of producing incorrect results

  • To ensure consistency in results over time and across different laboratories

  • Examples: validation of analytical methods used in pharmaceuticals, food testing, environmental monitoring, etc.

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Q5. How a protein is purified?

Ans.

Protein purification involves several steps including cell lysis, separation, and purification using chromatography.

  • The protein source is harvested and the cells are lysed to release the protein.

  • The protein is separated from other cellular components using techniques such as centrifugation or filtration.

  • The protein is purified using chromatography, which separates the protein based on its physical and chemical properties.

  • Different types of chromatography can be used, such as ...read more

Q6. What is IPC and Working Principal

Ans.

IPC stands for Inter-Process Communication. It is a mechanism that allows processes to communicate and synchronize with each other.

  • IPC allows processes to share data and communicate with each other

  • There are different types of IPC mechanisms such as pipes, message queues, shared memory, and sockets

  • Working principal involves sending and receiving messages between processes

  • Example: Using pipes to communicate between a parent process and a child process

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Q7. What's the pI represent?

Ans.

pI represents the isoelectric point of a molecule.

  • pI is the pH at which a molecule has no net charge.

  • It is the point where the acidic and basic groups of a molecule are balanced.

  • pI can be calculated using the pKa values of the acidic and basic groups.

  • For example, the pI of histidine is 7.6, which means it has no net charge at pH 7.6.

Q8. ICH guidelines

Ans.

ICH guidelines are a set of internationally recognized standards for the development, registration, and post-approval of pharmaceutical products.

  • ICH stands for International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use

  • ICH guidelines provide recommendations on various aspects of drug development, including quality, safety, efficacy, and multidisciplinary topics

  • Examples of ICH guidelines include Q1-Q14 guidelines, which cover topics such...read more

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Q9. Explain aex with example?

Ans.

AEX stands for Average Execution Time, a metric used to measure the average time taken to execute a process or task.

  • AEX is calculated by summing up the total execution time of a process and dividing it by the number of executions.

  • For example, if a process takes 10 seconds to execute and it is run 5 times, the AEX would be 10/5 = 2 seconds.

Q10. Give an example of AEX?

Ans.

AEX stands for Amsterdam Exchange, a stock exchange in the Netherlands.

  • AEX is a stock market index composed of the 25 most actively traded Dutch companies on the Amsterdam Exchange.

  • It is often used as a benchmark for the Dutch stock market.

  • Examples of companies included in the AEX index are Royal Dutch Shell, ASML, and Unilever.

Q11. Van dee meter equation

Ans.

The Van Dee meter equation is used to calculate the velocity of a fluid flow in a pipe.

  • The Van Dee meter equation is based on the principle of conservation of mass and energy.

  • It takes into account the pressure difference between two points in a pipe, the density of the fluid, and the pipe diameter.

  • The equation is typically used in fluid mechanics and engineering applications to determine flow rates.

  • Example: V = (2*(P1 - P2) / ρ) / (1 - (d2^4 / d1^4))^(1/2), where V is the vel...read more

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