Metrochem Api Interview Questions, Process, and Tips

To prepare the QC laboratory for an audit, follow these steps:

• Ensure all equipment is calibrated and validated

• Review and update standard operating procedures (SOPs)

• Train laboratory personnel on audit procedures and expectations

• Perform internal audits to identify and address any non-compliance issues

• Organize and maintain documentation, including records of test results and equipment maintenance

• Implement a robust quality...read more

An OOS investigation is a process to determine the cause of an out-of-specification result in a product or process.

• OOS stands for Out-of-Specification.

• It involves a thorough investigation to identify the root cause of the deviation.

• The investigation may include reviewing manufacturing records, conducting laboratory tests, and analyzing data.

• One example of an OOS investigation is when a pharmaceutical product fails to m...read more

Incident management process involves identifying, responding to, and resolving incidents to minimize their impact on business operations.

• The process starts with incident identification, where incidents are reported or detected.

• Once an incident is identified, it is logged and categorized based on its severity and impact.

• A response team is then assigned to investigate and resolve the incident.

• During the investigation, th...read more

Calibration of HPLC involves adjusting and verifying the accuracy and precision of the instrument.

• Calibration ensures that the HPLC system is performing accurately and reliably.

• It involves adjusting parameters such as flow rate, detector wavelength, and injection volume.

• Calibration standards of known concentration are used to verify the accuracy of the system.

• Precision is assessed by analyzing replicate injections of a...read more

Validation is the process of checking if something meets certain criteria. Types of validation include data validation, form validation, and email validation.

• Validation is the process of ensuring that something meets specific requirements or standards.

• Data validation involves checking the accuracy, completeness, and consistency of data.

• Form validation ensures that user input in web forms is correct and meets specified ...read more

To fix the specification limit for an unknown impurity in an API, conduct thorough analysis and consider regulatory guidelines.

• Perform comprehensive analysis of the impurity to determine its identity, properties, and potential risks

• Refer to regulatory guidelines and industry standards to establish acceptable limits for impurities

• Consider the impact of the impurity on the quality, safety, and efficacy of the API

• Collabor...read more

I have extensive experience working with water systems in various industrial settings.

• Experience with troubleshooting and repairing water pumps, valves, and pipelines

• Knowledge of water treatment processes and equipment

• Familiarity with water quality testing and analysis

• Implemented preventive maintenance programs to ensure efficient operation of water systems

IR spectroscopy and UV spectroscopy are analytical techniques used to study the interaction of matter with infrared and ultraviolet radiation, respectively.

• IR spectroscopy involves the absorption, transmission, and reflection of infrared radiation by a sample.

• UV spectroscopy measures the absorption of ultraviolet radiation by a sample.

• Both techniques are commonly used in chemistry to identify functional groups and anal...read more

Molarity is the concentration of a solution in moles of solute per liter of solution, while Normality is the concentration of a solution in equivalents of solute per liter of solution.

• Molarity is expressed in moles/L, while Normality is expressed in equivalents/L.

• Molarity is used for all types of solutions, while Normality is specifically used for acid-base reactions.

• To calculate Molarity, you need to know the molecula...read more

Oxidising reagents are substances that accept electrons, while reducing reagents are substances that donate electrons.

• Examples of oxidising reagents: potassium permanganate, hydrogen peroxide, nitric acid

• Examples of reducing reagents: sodium borohydride, lithium aluminum hydride, hydrogen gas

Proper handling of chemicals involves wearing appropriate protective gear, storing chemicals properly, and following safety guidelines.

• Always wear appropriate protective gear such as gloves, goggles, and lab coats when handling chemicals.

• Store chemicals in designated areas away from heat sources and incompatible substances.

• Follow safety guidelines provided by the manufacturer, including proper disposal methods and emer...read more

I am from a small town in the Midwest called Springfield.

• I grew up in a close-knit community surrounded by farmland

• The town has a population of around 10,000 people

• It is known for its annual county fair and historic downtown area