Metrochem Api Interview Questions, Process, and Tips

To prepare the QC laboratory for an audit, follow these steps:

• Ensure all equipment is calibrated and validated

• Review and update standard operating procedures (SOPs)

• Train laboratory personnel on audit procedures and expectations

• Perform internal audits to identify and address any non-compliance issues

• Organize and maintain documentation, including records of test results and equipment maintenance

• Implement a robust quality...read more

An OOS investigation is a process to determine the cause of an out-of-specification result in a product or process.

• OOS stands for Out-of-Specification.

• It involves a thorough investigation to identify the root cause of the deviation.

• The investigation may include reviewing manufacturing records, conducting laboratory tests, and analyzing data.

• One example of an OOS investigation is when a pharmaceutical product fails to m...read more

Incident management process involves identifying, responding to, and resolving incidents to minimize their impact on business operations.

• The process starts with incident identification, where incidents are reported or detected.

• Once an incident is identified, it is logged and categorized based on its severity and impact.

• A response team is then assigned to investigate and resolve the incident.

• During the investigation, th...read more

Calibration of HPLC involves adjusting and verifying the accuracy and precision of the instrument.

• Calibration ensures that the HPLC system is performing accurately and reliably.

• It involves adjusting parameters such as flow rate, detector wavelength, and injection volume.

• Calibration standards of known concentration are used to verify the accuracy of the system.

• Precision is assessed by analyzing replicate injections of a...read more

Validation is the process of checking if something meets certain criteria. Types of validation include data validation, form validation, and email validation.

• Validation is the process of ensuring that something meets specific requirements or standards.

• Data validation involves checking the accuracy, completeness, and consistency of data.

• Form validation ensures that user input in web forms is correct and meets specified ...read more

To fix the specification limit for an unknown impurity in an API, conduct thorough analysis and consider regulatory guidelines.

• Perform comprehensive analysis of the impurity to determine its identity, properties, and potential risks

• Refer to regulatory guidelines and industry standards to establish acceptable limits for impurities

• Consider the impact of the impurity on the quality, safety, and efficacy of the API

• Collabor...read more

Organic chemistry is the study of carbon-based compounds. pH measures acidity or alkalinity. TLC is a technique for separating compounds.

• Organic chemistry focuses on the study of carbon-containing compounds.

• pH is a measure of the acidity or alkalinity of a solution.

• TLC (Thin Layer Chromatography) is a technique used to separate and analyze compounds in a mixture.

• Polar solvents dissolve polar compounds, while non-polar ...read more

AA is a common abbreviation for amino acids. They have a general structure of NH2-CHR-COOH and can undergo various named reactions like Grignard reaction.

• AA stands for amino acids which are the building blocks of proteins

• Their general structure is NH2-CHR-COOH where R can be any of the 20 different side chains

• Grignard reaction is a named reaction used to form carbon-carbon bonds and is commonly used in organic synthesi

Density of solvents is an important property for various chemical processes.

• Density is the mass per unit volume of a substance.

• Solvents with higher density can dissolve more solutes.

• Density can be affected by temperature and pressure.

• Examples of solvents with different densities include water (1 g/mL), ethanol (0.789 g/mL), and chloroform (1.48 g/mL).