Executive

800+ Executive Interview Questions and Answers

Updated 16 Dec 2024

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Q1. How will you start RS method Development for known drug product?

Ans.

RS method development for known drug product involves identifying and separating enantiomers.

  • Identify the chiral center(s) in the drug molecule

  • Choose a suitable chiral stationary phase (CSP) for separation

  • Optimize mobile phase composition and flow rate

  • Validate the method for accuracy, precision, and specificity

  • Consider regulatory requirements for enantiomeric purity

  • Examples: RS method development for ibuprofen, omeprazole, etc.

Q2. What is peak purity and how it is calculated in hplc?

Ans.

Peak purity is a measure of the homogeneity of a chromatographic peak and is calculated using spectral data.

  • Peak purity is determined by comparing the spectral data of the peak at different wavelengths.

  • A peak with high purity will have a consistent spectral pattern across all wavelengths.

  • Peak purity can be calculated using software or manually by comparing the spectra.

  • Peak purity is important in ensuring accurate quantification and identification of compounds in a sample.

  • Exam...read more

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Q3. Procedure of export and import.China as country and as manufacturer and exporter.Where will you live as you are from different town and we will not provide resedence or hostel. Above 03 questions were asked in ...

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Ans.

The procedure of export and import in China as a country and manufacturer/exporter, and the challenge of finding accommodation in a different town.

  • Export and import procedures in China involve documentation, customs clearance, and transportation logistics.

  • As a manufacturer and exporter, understanding regulations, tariffs, and trade agreements is crucial.

  • Finding accommodation in a different town can be challenging, requiring research and planning.

  • Examples of export and import ...read more

Q4. How to use excell and basics of advance excellent

Ans.

Excel is a powerful tool for data analysis and management. Advanced Excel includes features like pivot tables, macros, and data validation.

  • Excel is used for organizing and analyzing data.

  • Basic Excel skills include creating spreadsheets, entering data, and using formulas.

  • Advanced Excel skills include pivot tables, macros, and data validation.

  • Pivot tables allow you to summarize and analyze large amounts of data.

  • Macros automate repetitive tasks in Excel.

  • Data validation ensures d...read more

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Q5. 1 - Which biological indicator use in autoclave validation at the time of RVSEB media cycle i.e. 115 C ?

Ans.

The biological indicator used in autoclave validation at 115 C is Geobacillus stearothermophilus.

  • Geobacillus stearothermophilus is a spore-forming bacterium that is highly resistant to heat and is commonly used as a biological indicator in autoclave validation.

  • It is used to ensure that the autoclave is effectively sterilizing equipment and materials at the desired temperature and pressure.

  • Other biological indicators, such as Bacillus atrophaeus, may be used for different temp...read more

Q6. How much orders are dispatch in last working organizations.

Ans.

I don't have the available data.

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    Q7. How to handle the failure during batch processing.

    Ans.

    To handle failure during batch processing, implement error handling mechanisms, monitor the process, and have a backup plan.

    • Implement error handling mechanisms such as exception handling and logging to capture and handle failures during batch processing.

    • Monitor the batch process regularly to identify any failures or errors and take appropriate actions to resolve them.

    • Have a backup plan in place to ensure that critical data is not lost or corrupted in case of a failure.

    • Conside...read more

    Q8. How to maintain delivery boys.,& critical situations in hubs

    Ans.

    To maintain delivery boys, provide incentives, clear communication, and a supportive work environment. In critical situations, have contingency plans in place.

    • Offer incentives such as bonuses or flexible schedules to keep delivery boys motivated and engaged.

    • Maintain clear communication channels to ensure that delivery boys are aware of their responsibilities and any changes in operations.

    • Create a supportive work environment by providing training, resources, and opportunities ...read more

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    Q9. Why if adding acid pH value get decreasing and adding alkali pH value is increasing

    Ans.

    The pH value decreases when acid is added and increases when alkali is added.

    • Acids release hydrogen ions (H+) when dissolved in water, which increases the concentration of H+ ions and lowers the pH value.

    • Alkalis release hydroxide ions (OH-) when dissolved in water, which decreases the concentration of H+ ions and raises the pH value.

    • The pH scale ranges from 0 to 14, with 7 being neutral. Values below 7 are acidic, and values above 7 are alkaline.

    • For example, adding lemon juic...read more

    Q10. Explain critical to quality parameters of process & how these are checked & what type of controls required to maintain these parameters

    Ans.

    Critical to quality parameters are essential for process control. They are checked through various methods and require specific controls.

    • Critical to quality parameters are the key characteristics of a product or service that must be controlled to ensure customer satisfaction.

    • These parameters are checked through various methods such as statistical process control, inspection, and testing.

    • Controls required to maintain these parameters include process controls, equipment control...read more

    Q11. How will you find water content mechanisma and importance of it.

    Ans.

    Water content mechanism can be found through various methods and is important for various reasons.

    • Water content can be measured through techniques such as gravimetric analysis, Karl Fischer titration, and moisture analyzers.

    • Water content is important in industries such as food, pharmaceuticals, and cosmetics to ensure product quality and stability.

    • Water content is also important in environmental studies to understand the water cycle and its impact on ecosystems.

    • In the human b...read more

    Q12. What are the different types of column in HPLC and how will you select the column?

    Ans.

    There are several types of columns in HPLC, including C18, C8, phenyl, and more. Column selection depends on the analyte and separation goal.

    • Common types of HPLC columns include C18, C8, phenyl, and more

    • Column selection depends on the analyte and separation goal

    • C18 columns are commonly used for hydrophobic compounds

    • Phenyl columns are useful for separating aromatic compounds

    • C8 columns are a good alternative to C18 for some applications

    • Other factors to consider when selecting a...read more

    Q13. Production department Clean room experience in clean room 4years

    Ans.

    Yes, I have 4 years of experience working in a clean room environment in the production department.

    • I have experience working with clean room protocols and procedures.

    • I am familiar with maintaining a sterile environment and following strict hygiene practices.

    • I have experience working with specialized equipment and tools used in clean room environments.

    • I am able to work efficiently and effectively in a clean room environment, ensuring high quality production standards are met.

    Q14. What are the type of sensor used in your company?

    Ans.

    We use a variety of sensors including temperature, pressure, humidity, and motion sensors.

    • Temperature sensors are used to monitor the temperature of equipment and environments.

    • Pressure sensors are used to measure pressure in systems such as pipelines and tanks.

    • Humidity sensors are used to measure the amount of moisture in the air.

    • Motion sensors are used to detect movement in areas where security is a concern.

    • Other sensors we use include light sensors, proximity sensors, and g...read more

    Q15. What are the system suitability criteria for RS and Assay method?

    Ans.

    System suitability criteria for RS and Assay method

    • RS: resolution between critical pairs should be greater than 1.5

    • Assay: accuracy, precision, linearity, range, specificity, LOD, LOQ

    • Acceptance criteria should be predefined and met

    • System suitability test should be performed before sample analysis

    Q16. What will be the total voltage accross the batteries in a 120kva ups?

    Ans.

    The total voltage across the batteries in a 120kVA UPS depends on the number and type of batteries used.

    • The voltage of each battery depends on its type and capacity

    • The number of batteries used in the UPS affects the total voltage

    • For example, if the UPS uses 12V batteries, 10 batteries would be needed to achieve a total voltage of 120V

    Q17. Compression machine Major breakdown and how to solve.

    Ans.

    A major breakdown in a compression machine and how to solve it.

    • Identify the cause of the breakdown

    • Check for any damaged parts and replace them

    • Perform regular maintenance to prevent future breakdowns

    • Consult with a professional if necessary

    Q18. What do you mean of FFS machine .

    Ans.

    FFS machine stands for Form-Fill-Seal machine, which is a packaging machine used to form, fill, and seal products in various industries.

    • FFS machine is commonly used in industries such as food and beverage, pharmaceuticals, and cosmetics.

    • It is an automated machine that can produce packaging materials on-site.

    • The machine forms a package from a flat roll of film, fills it with the product, and then seals it.

    • FFS machines can handle different types of packaging materials, includin...read more

    Q19. 2 - Name the 3 media which are use in microbiology analysis without sterilisation ?

    Ans.

    The three media used in microbiology analysis without sterilization are selective media, differential media, and enrichment media.

    • Selective media: These media contain specific nutrients or chemicals that inhibit the growth of certain microorganisms while allowing the growth of others. For example, MacConkey agar is a selective medium used to isolate and differentiate Gram-negative bacteria.

    • Differential media: These media contain indicators that allow the differentiation of di...read more

    Q20. What are test in Calibration of Dissolution and why we used prednisone?

    Ans.

    Calibration tests for dissolution involve using prednisone as a standard.

    • Prednisone is used as a standard because it is a commonly used drug and has a known dissolution rate.

    • Calibration tests ensure that the dissolution apparatus is functioning properly and producing accurate results.

    • Tests may include checking the temperature, pH, and agitation rate of the dissolution medium.

    • The results of calibration tests are used to adjust the apparatus and ensure that it meets regulatory ...read more

    Q21. What are the test in calibration of HPLC and why we used caffeine?

    Ans.

    Caffeine is used in HPLC calibration tests to determine the accuracy and precision of the instrument.

    • Caffeine is a common standard used in HPLC calibration tests because it is readily available, stable, and has a well-defined retention time.

    • The tests involve injecting a known amount of caffeine into the HPLC system and measuring its retention time and peak area.

    • The results are compared to established reference values to ensure the accuracy and precision of the instrument.

    • Othe...read more

    Q22. How to handle work pressure during the month end

    Ans.

    To handle work pressure during month end, prioritize tasks, delegate work, take breaks, and communicate with team members.

    • Prioritize tasks based on urgency and importance

    • Delegate work to team members who have the necessary skills and capacity

    • Take breaks to avoid burnout and maintain productivity

    • Communicate with team members to ensure everyone is on the same page and working towards the same goals

    • Use time management techniques such as the Pomodoro technique to stay focused and...read more

    Q23. How to use SAP , WPS , last mile.

    Ans.

    SAP, WPS, and last mile can be used together to optimize supply chain management.

    • SAP can be used for inventory management and tracking.

    • WPS can be used for workforce management and scheduling.

    • Last mile can be used for optimizing delivery routes and reducing transportation costs.

    • Integrating these tools can lead to more efficient and cost-effective supply chain management.

    • For example, SAP can provide real-time inventory data to WPS, allowing for more accurate scheduling of deliv...read more

    Q24. If set values of parameters affects to the product quality then it is a direct impact ; if does not affect then called non impact

    Ans.

    The impact of set values of parameters on product quality

    • Set values of parameters can have a direct impact on product quality

    • If the set values do not affect the product quality, it is considered non-impactful

    • Examples of parameters that can affect product quality include temperature, pressure, and time

    • Proper calibration and monitoring of parameters can ensure consistent product quality

    Q25. What is discrimination media in dissolution?

    Ans.

    Discrimination media in dissolution refers to the selective dissolution of certain components in a mixture.

    • It occurs when certain components dissolve faster or slower than others due to differences in solubility or chemical properties.

    • Examples include the dissolution of sugar in water, where sugar dissolves faster than other components like sand or salt.

    • In pharmaceuticals, discrimination media can be used to test the dissolution rate of different drug formulations.

    • It is impor...read more

    Q26. Why we are not using small micro size column in daily routine analysis

    Ans.

    Small micro size columns are not used in daily routine analysis due to limitations in sample capacity and resolution.

    • Small micro size columns have limited sample capacity, which may not be sufficient for routine analysis that requires larger sample volumes.

    • These columns also have limited resolution, which may not be suitable for complex analyses that require high separation power.

    • Using larger columns allows for higher sample throughput and better resolution, making them more ...read more

    Q27. What if a product is needed to be dispensed at priority but your pre-filters reading are out of limit?

    Ans.

    Consult with a supervisor to determine the best course of action.

    • Consult with a supervisor or team leader for guidance.

    • Consider the urgency of the situation and potential risks of using the product without proper filtration.

    • Check if there are any alternative filters or ways to bypass the pre-filters temporarily.

    • Communicate with relevant stakeholders about the issue and potential solutions.

    • Document the decision-making process and actions taken for future reference.

    Q28. When can you make contingent liability? What do you understand about probable, possible and remote cases?

    Ans.

    Contingent liabilities are recognized when it is probable that a liability will occur and the amount can be reasonably estimated.

    • Contingent liabilities are recognized when it is probable that a liability will occur and the amount can be reasonably estimated.

    • Probable cases are those where the occurrence of the liability is likely based on available evidence.

    • Possible cases are those where the occurrence of the liability is more than remote but less than probable.

    • Remote cases ar...read more

    Q29. If you get a customer feedback what is the first thing you will do?

    Ans.

    The first thing I would do is acknowledge the customer feedback and thank them for taking the time to provide it.

    • Acknowledge the customer feedback

    • Thank the customer for their feedback

    • Assure the customer that their feedback is valuable and will be taken into consideration

    • Ask for any additional details or clarification if needed

    • Take necessary steps to address the feedback and improve the customer experience

    Q30. What is inheritance, describe polymorphism, Tell me some Java 8 features, how stack works, differentiate between stack and queue considering their working, describe enhanced for loop in java, differentiate betw...

    read more
    Ans.

    Inheritance is a mechanism in which a new class inherits properties and behaviors from an existing class. Polymorphism allows objects of different classes to be treated as objects of a common superclass.

    • Java 8 features include lambda expressions, functional interfaces, streams, and default methods.

    • Stack is a data structure that follows the Last In First Out (LIFO) principle, while a queue follows the First In First Out (FIFO) principle.

    • Enhanced for loop in Java is used to ite...read more

    Q31. How to prepare 20 ppm solution, how to prepare specification and stps from phatmacopoea, current volume of IP, usp and BP and lastly about my interest in either in documentation or analysis.

    Ans.

    The interview question covers topics on preparing a 20 ppm solution, creating specifications and STPs from pharmacopoeia, current volumes of IP, USP, and BP, and interest in documentation or analysis.

    • To prepare a 20 ppm solution, dissolve 20 mg of the solute in 1 liter of the solvent.

    • Specifications and STPs can be created by following the guidelines provided in the relevant pharmacopoeia.

    • The current volumes of IP, USP, and BP can be found on their respective websites or by co...read more

    Q32. Which type of action you taking while your product analysis result came out of limit ??

    Ans.

    When the product analysis result is out of limit, I take immediate action to investigate the issue and implement corrective measures.

    • Identify the cause of the out-of-limit result

    • Evaluate the impact on product quality and safety

    • Implement corrective actions to bring the product within acceptable limits

    • Communicate the findings and actions to relevant stakeholders

    • Monitor the effectiveness of the corrective measures

    Q33. How recover loss on your Area & how to handle manpower in all areas?

    Ans.

    To recover loss on my area, I would analyze the reasons for the loss and implement strategies to improve performance. To handle manpower, I would ensure proper training and communication.

    • Analyze reasons for loss and implement strategies to improve performance

    • Identify areas of improvement and set achievable goals

    • Ensure proper training and communication for manpower

    • Regularly monitor and evaluate performance

    • Provide incentives and recognition for good performance

    Q34. Difference between ETP & MEE, What is cost of per litre of treatment of water from ETP & MEE, What is RO & its principle, Purpose of Zero Liquid Discharge & its implementation by securing permissible limits for...

    read more
    Ans.

    ETP & MEE are water treatment systems, RO is a filtration process, ZLD aims to reuse treated water by meeting permissible limits.

    • ETP (Effluent Treatment Plant) treats industrial wastewater, while MEE (Multiple Effect Evaporator) is used for concentrating wastewater.

    • Cost per litre of treatment from ETP is typically lower than MEE due to differences in technology and energy consumption.

    • RO (Reverse Osmosis) is a filtration process that uses a partially permeable membrane to remo...read more

    Q35. 3 - Why E.coli colony found red brick on Macconkey agar plates ?

    Ans.

    E.coli colony found red brick on Macconkey agar plates due to lactose fermentation.

    • E.coli is a lactose fermenting bacteria

    • Macconkey agar is a selective and differential media used to isolate and differentiate lactose fermenting bacteria

    • Lactose fermentation produces acid which lowers the pH of the agar and changes the color of the indicator from yellow to red

    • E.coli colonies appear as red brick on Macconkey agar plates

    Q36. Explain how to design of cooling tower, HE, Reactor, Column , Scrubber ??

    Ans.

    Designing cooling towers, HE, reactors, columns, and scrubbers involves considering various factors such as heat transfer, fluid dynamics, and material selection.

    • Determine the required heat transfer rate and flow rate for the process

    • Select appropriate materials based on the process conditions and corrosion resistance

    • Consider the fluid dynamics and pressure drop across the equipment

    • Design for ease of maintenance and cleaning

    • Examples of design considerations include packing mat...read more

    Q37. What is the key of remove duplicates

    Ans.

    The key to remove duplicates is to iterate through the array and keep track of unique elements.

    • Iterate through the array and compare each element with the rest of the elements.

    • If a duplicate is found, remove it from the array.

    • Keep track of unique elements using a hash set or dictionary.

    • Return the modified array with duplicates removed.

    Q38. What is the Purpose of changing the current company?

    Ans.

    Changing companies can provide new opportunities for growth and development.

    • To seek new challenges and experiences

    • To advance career goals

    • To improve work-life balance

    • To escape a toxic work environment

    • To pursue a passion or interest

    • To increase salary or benefits

    • To relocate to a new city or country

    Q39. How will you delevope method on HPLC and types of coloumn

    Ans.

    Developing HPLC methods involves selecting appropriate columns and optimizing parameters.

    • Choose a suitable column based on the analyte's properties and the separation goal.

    • Optimize parameters such as mobile phase composition, flow rate, and temperature.

    • Validate the method by assessing its selectivity, sensitivity, accuracy, and precision.

    • Common column types include C18, C8, and phenyl.

    • Other factors to consider include column dimensions, particle size, and pore size.

    • HPLC metho...read more

    Q40. In case centrifuge bag cut What do?

    Ans.

    In case the centrifuge bag is cut, take immediate action to prevent contamination and ensure safety.

    • Immediately stop the centrifuge and power it off.

    • Isolate the cut bag to prevent any potential contamination.

    • Wear appropriate personal protective equipment (PPE) such as gloves and a lab coat.

    • Transfer the contents of the cut bag to a new, intact bag using sterile techniques.

    • Dispose of the cut bag and any contaminated materials properly.

    • Clean and disinfect the centrifuge and surr...read more

    Q41. What is the procedure of receipt of Raw material and Packing material?

    Ans.

    Raw material and packing material are received through a structured procedure to ensure quality and traceability.

    • Raw material and packing material are typically received at a designated receiving area in the warehouse.

    • Upon arrival, the materials are checked against the purchase order to ensure accuracy.

    • Quality checks may be performed to verify the condition and specifications of the materials.

    • The materials are then labeled, stored in designated areas, and logged into the inve...read more

    Q42. What does SA 402 says? What type of report does it prescribe?

    Ans.

    SA 402 is a standard on auditing of accounting estimates and related disclosures. It prescribes an auditor's report.

    • SA 402 provides guidance on auditing accounting estimates and related disclosures.

    • It requires the auditor to evaluate the reasonableness of accounting estimates made by management.

    • The standard also emphasizes the importance of disclosures related to accounting estimates in financial statements.

    • SA 402 prescribes the format and content of the auditor's report when...read more

    Q43. What is cutoff procedure? How do you perform it? Why it is performed?

    Ans.

    Cutoff procedure is a process of determining a specific point in time for ending a particular activity or transaction.

    • Cutoff procedure is performed to ensure accurate financial reporting by capturing all relevant transactions within a specific period.

    • It involves setting a specific date and time to stop recording transactions for a particular period, such as month-end or year-end.

    • The procedure includes reviewing and adjusting entries to ensure all transactions are properly acc...read more

    Q44. During Compression Line Clearance, if the weight of the Blend is less than the Given Limit,as a IPQA what is ur Action

    Ans.

    If the weight of the Blend is less than the Given Limit during Compression Line Clearance, the IPQA should take appropriate action.

    • The IPQA should immediately stop the compression process.

    • They should inform the production team and supervisor about the issue.

    • Investigate the cause of the weight discrepancy, such as equipment malfunction or incorrect formulation.

    • Document the incident and any observations made during the process.

    • Take necessary corrective actions to ensure the ble...read more

    Q45. Criteria of batch size selection for commercial products

    Ans.

    Batch size selection for commercial products depends on various factors.

    • Batch size should be based on market demand and production capacity.

    • Cost of production and inventory management should also be considered.

    • Regulatory requirements and shelf life of the product are important factors.

    • Batch size can vary depending on the complexity of the manufacturing process.

    • Examples: Pharmaceutical companies may produce smaller batches for clinical trials and larger batches for commercial ...read more

    Q46. How to make sure Dispatch to fulfill customer Demand

    Ans.

    Ensure efficient dispatch by optimizing routes, tracking inventory, and prioritizing urgent orders.

    • Implement a route optimization software to minimize travel time and fuel costs.

    • Maintain accurate inventory records to avoid stockouts and delays.

    • Prioritize urgent orders and communicate any delays to customers.

    • Train dispatchers to handle unexpected situations and make quick decisions.

    • Regularly review and analyze dispatch data to identify areas for improvement.

    Q47. How will you decide limit for unknown impurity?

    Ans.

    The limit for unknown impurity is decided based on the safety and efficacy of the drug.

    • The limit should be set below the level that may cause harm to patients.

    • The limit should be based on the analytical method used to detect the impurity.

    • The limit should be reviewed periodically and updated if necessary.

    • The limit should be justified and documented in the drug's regulatory submission.

    • For example, if the impurity is a known carcinogen, the limit should be set as low as reasonab...read more

    Q48. What is the mean of Direct impact and No impact systems

    Ans.

    The mean of Direct impact and No impact systems is undefined.

    • Direct impact and No impact systems are not comparable in terms of impact.

    • Direct impact systems have a significant impact on the organization or process, while No impact systems have no impact.

    • Therefore, calculating the mean of these two types of systems is not meaningful.

    • It is important to evaluate the impact of each system separately and make decisions accordingly.

    Q49. What are the changes between CARO 2020 and CARO 2016?

    Ans.

    CARO 2020 introduced significant changes compared to CARO 2016.

    • Expanded scope of reporting requirements

    • Introduction of new reporting formats

    • Enhanced focus on fraud detection and reporting

    • Increased responsibilities for auditors

    • Additional disclosures related to related party transactions

    Q50. What are the levels in Linearity and Accuracy in RS

    Ans.

    Linearity and accuracy are important measures in remote sensing. Linearity refers to the relationship between input and output values, while accuracy refers to the closeness of measured values to true values.

    • Linearity measures the consistency of the relationship between input and output values

    • Accuracy measures the closeness of measured values to true values

    • Linearity and accuracy are important for ensuring reliable and consistent remote sensing data

    • Examples of factors that can...read more

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