Alkem Laboratories Research Scientist Interview Questions and Answers

The role of a ligand in Suzuki coupling reaction is to facilitate the formation of a stable complex between the catalyst and the reactants.

• A ligand coordinates with the catalyst metal center, enhancing its reactivity and selectivity.

• It helps in stabilizing the transition state and lowering the activation energy of the reaction.

• Different ligands can influence the reaction rate and product distribution.

• Common ligands use...read more

I am well-versed with the mechanism of the Grignard reaction.

• Grignard reaction involves the addition of an organomagnesium halide to a carbonyl compound.

• It is a nucleophilic addition reaction.

• The reaction is highly useful in organic synthesis, especially for the formation of carbon-carbon bonds.

• Examples include the synthesis of alcohols, carboxylic acids, and ketones.

• The reaction is named after French chemist Victor Gr

The percentage of buffer used in mobile phase and the use of SLS in disso and its allowed percentage.

• The percentage of buffer used in the mobile phase depends on the specific experiment and the desired separation of compounds.

• Buffer is used in the mobile phase to maintain the pH and ionic strength, which can affect the separation and stability of analytes.

• The percentage of buffer can range from 5% to 50% or more, depen...read more

The sink condition is decided based on various factors such as the purpose of the sink, the type of research being conducted, and the desired outcome.

• Consider the purpose of the sink - Is it for disposal, storage, or analysis of substances?

• Evaluate the type of research being conducted - Does it involve chemical reactions, biological samples, or physical measurements?

• Assess the desired outcome - Are you looking for pres...read more

The criteria/limit for impurity recovery depends on the specific research study and the desired purity level.

• The criteria for impurity recovery may include the maximum allowable impurity concentration or percentage.

• The limit for impurity recovery can be determined based on regulatory guidelines or industry standards.

• The desired purity level may vary depending on the application or intended use of the research findings.

• ...read more

Mass balance is a principle used in various scientific disciplines to account for the mass of substances in a system.

• Mass balance is based on the principle of conservation of mass, which states that mass cannot be created or destroyed, only transferred or transformed.

• It involves tracking the inputs, outputs, and accumulation of mass within a system.

• Mass balance equations are commonly used in environmental science, chem...read more

RF values are important in chromatography to identify and separate compounds.

• RF value is the ratio of the distance traveled by a compound to the distance traveled by the solvent front in chromatography.

• It helps in identifying and separating compounds based on their polarity and solubility.

• RF values can be used to compare compounds and determine their purity.

• For example, in thin-layer chromatography, RF values are used ...read more