Lupin Executive Quality Control Interview Questions and Answers

Investigation of OOS involves thorough analysis of data, procedures, and potential root causes to determine the reason for the out-of-specification result.

• Review all relevant data and documentation related to the OOS result.

• Conduct a detailed investigation into the testing procedures and equipment used.

• Consider potential environmental factors that may have influenced the result.

• Identify any deviations from standard ope...read more

The number of weights in a balance calibration weight box varies depending on the specific box.

• The number of weights can range from a few to several dozen, depending on the precision required for calibration.

• Common calibration weight boxes may contain weights ranging from 1 gram to 500 grams.

• Some calibration weight boxes may also include additional weights for fine adjustments.

• The exact number of weights in a box can b...read more

Weights can be differentiated by their units of measurement (mg, g), and by their numerical value (2, 20, 200).

• Differentiate by units of measurement (mg, g)

• Differentiate by numerical value (2, 20, 200)

Theoretical plates are considered as system suit because they help in separating and purifying components in a system.

• Theoretical plates are used in chromatography to separate and purify components in a mixture.

• They are considered as system suit because they help in achieving a high degree of separation efficiency.

• The more theoretical plates a system has, the better it is at separating components.

• Theoretical plates are...read more

Water content can be calculated by subtracting the weight of the dry sample from the weight of the sample after drying.

• Water content = (Weight of wet sample - Weight of dry sample) / Weight of dry sample

• Dry the sample in an oven at a specific temperature until it reaches a constant weight

• Weigh the sample before and after drying to determine the weight loss

• Water content is usually expressed as a percentage

Similarity factor (recovery factor) is calculated to assess the similarity between two dissolution profiles.

• Similarity factor is a measure of the closeness of two dissolution profiles.

• It is calculated using the mean and standard deviation of the percent dissolved values at each time point.

• The formula for similarity factor is SF = 50 * log((1 + (1/n) * Σ(|R-T|/R)) / (1 + (1/n) * Σ(|R-T|/T))), where R is the reference pr...read more