300+ Quality Controller Interview Questions and Answers

Chemistry is the study of matter and its properties. Organic chemistry deals with carbon-based compounds while inorganic chemistry deals with non-carbon-based compounds.

• Chemistry is a branch of science that deals with the composition, structure, properties, and reactions of matter.

• Organic chemistry is the study of carbon-based compounds, including hydrocarbons, carbohydrates, proteins, and nucleic acids.

• Inorganic chemistry is the study of non-carbon-based compounds, including...read more

HPLC stands for High Performance Liquid Chromatography. It is a technique used to separate, identify, and quantify components in a mixture.

• HPLC is based on the principle of separating components in a mixture using a liquid mobile phase that carries the sample through a stationary phase.

• TLC stands for Thin Layer Chromatography, which is a technique for separating and analyzing mixtures based on their differential migration on a thin layer of adsorbent material.

• Chromatography i...read more

Nucleic acids are biomolecules essential for storing and transmitting genetic information in cells.

• Nucleic acids are made up of nucleotides, which consist of a sugar, a phosphate group, and a nitrogenous base.

• There are two types of nucleic acids: DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).

• DNA carries genetic information and is responsible for inheritance, while RNA plays a role in protein synthesis.

• Nucleic acids are crucial for the replication and expression of ge...read more

PCR is a technique used to amplify a specific DNA sequence, producing millions of copies for analysis.

• PCR involves cycles of heating and cooling to denature, anneal, and extend DNA strands.

• Types of PCR include conventional PCR, quantitative PCR (qPCR), reverse transcription PCR (RT-PCR), and digital PCR.

• Conventional PCR is used for DNA amplification, qPCR for quantifying DNA, RT-PCR for RNA amplification, and digital PCR for absolute quantification.

Nucleic acids are macromolecules made up of nucleotides, while nucleosides are smaller molecules composed of a nitrogenous base and a sugar.

• Nucleic acids are polymers made up of nucleotides, which consist of a nitrogenous base, a sugar, and a phosphate group.

• Examples of nucleic acids include DNA and RNA.

• Nucleosides are smaller molecules composed of a nitrogenous base and a sugar, but they lack the phosphate group found in nucleotides.

• Examples of nucleosides include adenosine ...read more

Real-Time PCR allows for monitoring the amplification of DNA in real-time, while conventional PCR requires post-amplification analysis.

• Real-Time PCR provides quantitative data in real-time, while conventional PCR only provides qualitative data after the reaction is complete.

• Real-Time PCR uses fluorescent dyes or probes to monitor amplification as it occurs, while conventional PCR relies on gel electrophoresis to visualize the final products.

• Real-Time PCR is more sensitive and...read more

DNA extraction and isolation is the process of obtaining DNA from cells for further analysis.

• Cells are lysed to release DNA

• Proteins and other contaminants are removed through precipitation or column purification

• DNA is then precipitated and washed to remove impurities

• Finally, DNA is resuspended in a buffer for storage or analysis

Shuttering can be managed without removing supports under slab and pourstrip by using adjustable props and beams.

• Use adjustable props to support the slab and pourstrip while removing the shuttering.

• Install beams to transfer the load from the slab to the props, allowing the supports to be removed.

• Ensure proper alignment and spacing of props and beams to distribute the load evenly.

• Regularly check and adjust the props and beams to maintain stability during the construction proce...read more

I will identify the root cause of the problem, implement corrective actions, and monitor the effectiveness of the solutions.

• Investigate the issue to determine the root cause

• Implement corrective actions to address the problem

• Monitor the effectiveness of the solutions to ensure the problem is resolved

• Document the entire process for future reference

To convert reverse phase to normal phase in HPLC, change the stationary phase from non-polar to polar.

• Replace the non-polar stationary phase with a polar one

• Use a polar mobile phase

• Adjust the pH of the mobile phase to match the pKa of the analyte

• Optimize the gradient elution conditions

• Verify the separation using appropriate standards

The role of a quality controller during production is to ensure that products meet the required standards and specifications.

• Monitoring and inspecting production processes

• Identifying defects and deviations from standards

• Implementing corrective actions to prevent defects

• Maintaining records and documentation of quality control activities

• Collaborating with production teams to improve processes

• Ensuring compliance with regulatory requirements

• Conducting audits and quality assessmen...read more

Harmful bacteria and their limits vary depending on the context and industry.

• Common harmful bacteria include Salmonella, E. coli, and Listeria.

• Limits for harmful bacteria in food are regulated by government agencies.

• In the medical field, harmful bacteria can cause infections and diseases.

• Different industries have specific guidelines for acceptable levels of bacteria.

• Regular testing and quality control measures are essential to ensure safety.

Quality checking involves inspecting products or services to ensure they meet certain standards.

• Quality checking involves examining products or services to ensure they meet certain standards

• This can involve visual inspection, testing, or other methods depending on the product or service

• Experience in quality checking can vary, but typically requires knowledge of industry standards and regulations

• To check the quality status, one must compare the product or service to establishe...read more

Minimum compressive strength of OPC 43 grade cement is 43 MPa.

• OPC 43 grade cement has a minimum compressive strength of 43 MPa

• The compressive strength of cement is a measure of its ability to withstand compressive loads

• OPC stands for Ordinary Portland Cement

• The grade of cement indicates its strength and quality

HPLC stands for High Performance Liquid Chromatography. It is a technique used to separate, identify, and quantify components in a mixture.

• HPLC is based on the principle of separating components in a mixture using a liquid mobile phase and a solid stationary phase.

• TLC (Thin Layer Chromatography) is another chromatographic technique where the stationary phase is a thin layer of adsorbent material on a flat support.

• Chromatography is a technique used to separate and analyze mixt...read more

There are 118 elements in the periodic table.

• There are 118 known elements in the periodic table.

• Elements are organized by atomic number, electron configuration, and recurring chemical properties.

• Examples of elements include hydrogen, oxygen, gold, and uranium.

Quality checking involves inspecting products or services to ensure they meet standards. Experience and attention to detail are key.

• Quality checking involves inspecting products or services to ensure they meet standards

• This can include visual inspections, measurements, and testing

• Experience and attention to detail are key in identifying potential issues and ensuring quality

• Quality checking can involve using tools such as checklists, statistical process control, and quality co...read more

UV spectroscopy is a technique used to analyze the absorption and transmission of ultraviolet light by a sample.

• UV spectroscopy involves measuring the absorbance of ultraviolet light by a sample.

• It works based on the principle that molecules absorb UV light at specific wavelengths.

• The amount of absorption is proportional to the concentration of the absorbing species in the sample.

• UV spectroscopy is commonly used in pharmaceutical, environmental, and biochemical analysis.

IS codes specify a minimum mixing time for concrete to ensure uniformity and strength, typically around 2 to 5 minutes.

• The minimum mixing time for concrete is generally 2 minutes for a concrete mixer.

• For larger batches, the mixing time can extend to 5 minutes to ensure proper consistency.

• Different types of mixers may have varying mixing times; for instance, a pan mixer may require less time than a drum mixer.

• It's crucial to adhere to these times to achieve the desired workabi...read more

Climatic fruits and vegetables are those that require specific climate conditions to grow, while non-climatic ones can grow in various climates.

• Climatic fruits and vegetables need specific temperature, humidity, and sunlight conditions to thrive

• Non-climatic fruits and vegetables can grow in a wider range of climates

• Examples of climatic fruits: bananas, pineapples, mangoes

• Examples of non-climatic fruits: apples, oranges, strawberries

• Examples of climatic vegetables: tomatoes, c...read more

KYC is a process used by businesses to verify the identity of their clients to prevent fraud and ensure compliance with regulations.

• 1. Customer Identification: Collect personal information such as name, address, and date of birth.

• 2. Document Verification: Validate identity documents like passports or driver's licenses.

• 3. Risk Assessment: Evaluate the customer's risk level based on their profile and transaction behavior.

• 4. Ongoing Monitoring: Continuously monitor transactions ...read more

The presence of chlorine can be confirmed by adding nitric acid and silver nitrate to a sample, resulting in a curdy white precipitate.

• Mix 1 ml sample with 5 ml nitric acid and 5 ml silver nitrate

• Add 10 ml water and observe for curdy white precipitate

• Presence of chlorine confirmed if precipitate forms

I have extensive technical knowledge of pharmaceutical production.

• I am familiar with Good Manufacturing Practices (GMP) and Quality Control (QC) procedures.

• I have experience in operating and maintaining production equipment such as tablet presses, capsule fillers, and packaging machines.

• I am knowledgeable in the formulation and compounding of pharmaceutical products.

• I am familiar with the various stages of pharmaceutical production, including raw material testing, in-process ...read more

The Listcount of vernier caliper & micrometers is 2.

• The Listcount of vernier caliper is 1.

• The Listcount of micrometers is 1.

Different types of measuring tools include rulers, calipers, micrometers, tape measures, and gauges.

• Ruler - used for measuring straight lines and lengths

• Calipers - used for measuring the distance between two opposite sides of an object

• Micrometers - used for measuring very small distances or thicknesses

• Tape measure - used for measuring longer distances or circumferences

• Gauges - used for measuring specific dimensions or parameters

Quality control measures ensure products meet standards, enhancing safety and reliability across various industries.

• IS 15000: Focuses on quality management systems in manufacturing processes.

• IS 9001: Establishes criteria for a quality management system, applicable to any organization.

• IS 13485: Specific to medical devices, ensuring consistent quality in design and manufacturing.

• IS 14001: Addresses environmental management, promoting sustainable practices in quality control.

• IS ...read more

Quality assurance for a product should start at the beginning of the product development process.

• Start quality assurance during the design phase to prevent issues from arising later on

• Implement quality control measures during manufacturing to ensure consistency and reliability

• Conduct regular inspections and testing throughout the production process

• Involve stakeholders in the quality assurance process to gather feedback and make improvements

• Continuously monitor and evaluate th...read more