40+ Interview Questions and Answers

If the weight of the Blend is less than the Given Limit during Compression Line Clearance, the IPQA should take appropriate action.

• The IPQA should immediately stop the compression process.

• They should inform the production team and supervisor about the issue.

• Investigate the cause of the weight discrepancy, such as equipment malfunction or incorrect formulation.

• Document the incident and any observations made during the process.

• Take necessary corrective actions to ensure the ble...read more

To convert reverse phase to normal phase in HPLC, change the stationary phase from non-polar to polar.

• Replace the non-polar stationary phase with a polar one

• Use a polar mobile phase

• Adjust the pH of the mobile phase to match the pKa of the analyte

• Optimize the gradient elution conditions

• Verify the separation using appropriate standards

CEP approval timelines vary depending on the complexity of the application and the workload of the EDQM.

• CEP applications are reviewed by the European Directorate for the Quality of Medicines (EDQM)

• The review process can take anywhere from 6 to 18 months

• The complexity of the application and workload of the EDQM can affect the timeline

• CEP approvals are valid for 5 years and can be renewed

• CEPs are recognized by regulatory authorities in over 40 countries

The guidelines followed for nitrosamine limits are set by regulatory agencies such as FDA, EMA, and ICH.

• Nitrosamine limits are set by regulatory agencies to ensure the safety of pharmaceutical products.

• FDA has set a limit of 96 ng/day for nitrosamines in certain medications.

• EMA has set a limit of 26.5 ppm for nitrosamines in sartan medicines.

• ICH has issued guidelines for the detection and control of nitrosamines in pharmaceuticals.

The question covers topics related to process engineering in production, including boiling point, types of equipment, cGMP, change control, quality control, and handling of various equipment.

• Boiling point is the temperature at which a substance changes from a liquid to a gas.

• Types of agitators include paddle agitators, anchor agitators, and turbine agitators.

• Types of reactors include batch reactors, continuous stirred tank reactors, and plug flow reactors.

• cGMP stands for curr...read more

Setting a gun to bed involves safely storing and securing the firearm.

• Unload the gun and remove any ammunition

• Store the gun in a locked safe or cabinet

• Keep the gun and ammunition separate

• Use trigger locks or cable locks for added security

• Follow local laws and regulations regarding gun storage

Fermentation is a process of converting sugars into alcohol or organic acids. Chromatography is a technique used to separate and analyze mixtures.

• Fermentation is used in the production of alcoholic beverages like beer and wine.

• It is also used in the production of bread, yogurt, and cheese.

• Chromatography is used in the separation and purification of complex mixtures like proteins and DNA.

• It is used in various fields like pharmaceuticals, forensics, and environmental testing.

• Th...read more

Power transformers require various protection measures to ensure their safe and reliable operation.

• Overcurrent protection to prevent excessive current flow

• Differential protection to detect internal faults

• Buchholz relay to detect and prevent transformer oil and gas faults

• Temperature monitoring to prevent overheating

• Voltage protection to safeguard against overvoltage

• Ground fault protection to detect and isolate ground faults

• Winding temperature indicators to monitor winding temp...read more

To increase pan RPM, adjust the speed control settings, increase power input, or optimize the pan's weight distribution.

• Check the speed control settings and increase the RPM limit if necessary.

• Increase the power input to the pan by adjusting the power supply or using a more powerful motor.

• Optimize the weight distribution of the pan by redistributing the load or using counterweights.

• Ensure that the pan is properly lubricated to reduce friction and allow for smoother rotation.

The number of sizes of coating pans varies depending on the manufacturer and specific requirements.

• The number of sizes of coating pans can range from a few standard sizes to a wide range of options.

• Manufacturers may offer coating pans in sizes such as 12 inches, 18 inches, 24 inches, etc.

• The size of the coating pan is determined by the capacity and the desired batch size of the coating process.

• Different sizes of coating pans may be used for different applications or productio...read more

We can use a Class CT for differential protection.

• Class CTs are commonly used for differential protection in electrical engineering.

• Class CTs provide accurate current measurement and can detect small differences in current flow.

• They are often used in applications such as transformer differential protection and motor protection.

• Class CTs are designed to have a high accuracy and low saturation level to ensure reliable differential protection.

• Examples of Class CTs commonly used ...read more

Negative pressure is set by adjusting the airflow in a controlled environment.

• Negative pressure is created by ensuring that the exhaust airflow is greater than the supply airflow.

• This can be achieved by adjusting dampers or vents to control the airflow.

• Negative pressure is commonly used in environments like cleanrooms, isolation rooms, or laboratories to prevent the spread of contaminants.

• For example, in a hospital isolation room, the exhaust fan is set to a higher speed than...read more

The flow of water, methanol, and isopropanol can be determined by measuring their respective viscosities and densities.

• Viscosity and density of each liquid must be measured

• The flow rate can be calculated using the Hagen-Poiseuille equation

• The flow rate will vary depending on the pipe diameter and pressure

• The flow rate can be optimized by adjusting the pipe diameter and pressure

• The flow rate of each liquid can be compared to ensure consistency

There is no magic solution.

• There is no one-size-fits-all solution for quality control.

• Quality control requires a combination of various techniques and processes.

• Continuous improvement and adaptation are key in quality control.

• Examples of quality control techniques include statistical process control, Six Sigma, and Lean manufacturing.

Spray pump increase can lead to various problems.

• Increased spray pump pressure can cause leaks or bursts in the system.

• Higher pump pressure can result in excessive spray application, leading to wastage of resources.

• Increased pump pressure may cause uneven spray distribution, resulting in poor coverage.

• Higher pump pressure can also lead to increased wear and tear on the pump components, reducing its lifespan.

• Excessive pump pressure can cause damage to delicate surfaces or plan...read more

HVAC stands for Heating, Ventilation, and Air Conditioning.

• HVAC is a system used to control the temperature, humidity, and air quality in a building.

• It includes heating, cooling, ventilation, and air filtration systems.

• HVAC systems are commonly used in residential, commercial, and industrial buildings.

• Examples of HVAC equipment include air conditioners, furnaces, boilers, and ductwork.

• Proper maintenance of HVAC systems is important for energy efficiency and indoor air quality...read more

Deficiencies in regulatory compliance are increasing due to stricter regulations and increased scrutiny.

• Stricter regulations are being implemented by regulatory bodies

• Increased scrutiny by regulatory bodies

• Non-compliance with regulations due to lack of understanding or resources

• Increased focus on data integrity and quality

• Increased emphasis on risk management

• Examples include FDA warning letters for data integrity issues and EU MDR non-compliance

I have extensive experience in leadership roles and a proven track record of successfully managing teams and achieving targets.

• Strong leadership skills demonstrated through previous roles

• Proven track record of meeting and exceeding targets

• Excellent communication and interpersonal skills

• Ability to motivate and inspire team members

• Experience in strategic planning and decision-making

Critical instruments should be calibrated more frequently than non-critical instruments to ensure accuracy and reliability.

• Critical instruments should be calibrated at least once a month or as recommended by the manufacturer.

• Non-critical instruments can be calibrated less frequently, such as once a year.

• Regular calibration ensures accurate measurements and reliable performance of instruments.

• Examples: Critical instruments may include temperature sensors in a pharmaceutical ma...read more

Spray pattern is used to achieve uniform coverage and efficient application of a substance.

• Spray pattern helps in evenly distributing the substance being sprayed.

• It ensures that the substance reaches the desired target area effectively.

• Different spray patterns can be used depending on the application requirements.

• Examples of spray patterns include fan, cone, flat, and mist patterns.

Qualification and validation are two important processes in ensuring the quality and reliability of products and processes.

• Qualification is the process of demonstrating that equipment or systems are suitable for their intended use.

• Validation is the process of establishing documented evidence that a process or system consistently produces a product or result that meets predetermined specifications and quality attributes.

• Qualification and validation are often required in regula...read more

The pan increase in problems refers to a sudden surge in the number of issues or challenges.

• There has been a significant rise in the number of problems across various areas.

• The increase in problems is affecting the overall efficiency and productivity.

• Identifying the root causes of the problems is crucial to finding effective solutions.

• Implementing proactive measures can help mitigate the impact of the increased problems.

• Regular monitoring and analysis of the problem trends ca...read more

Pharma products refer to medications and drugs used for the prevention, treatment, and management of various diseases and medical conditions.

• Pharma products are developed through extensive research and clinical trials.

• They are regulated by government agencies such as the FDA.

• Pharma products can be prescription or over-the-counter (OTC) medications.

• Examples of pharma products include antibiotics, pain relievers, and vaccines.

• Pharma products can have side effects and interactio...read more

API stands for Application Programming Interface. It is a set of protocols, routines, and tools for building software applications.

• API allows different software applications to communicate with each other

• It defines how software components should interact

• APIs can be public or private

• Examples of APIs include Google Maps API, Twitter API, and Facebook API

Process validation is the documented evidence that a process is capable of consistently producing a product that meets its predetermined specifications and quality attributes.

• Process validation is a critical part of quality assurance in manufacturing.

• It involves testing and verifying that a process consistently produces a product that meets its specifications.

• Process validation typically involves three stages: process design, process qualification, and continued process verif...read more

I have faced audits in my previous role as a Deputy Manager.

• I have faced audits from both internal and external auditors.

• I have experience in preparing for audits, gathering necessary documentation, and participating in audit meetings.

• I have successfully addressed audit findings and implemented corrective actions to improve processes.

• I have been involved in audits related to financial records, compliance with regulations, and operational procedures.

I recently observed discrepancies in inventory management during an audit.

• Identified inconsistencies in inventory records vs physical count

• Noted lack of proper documentation for inventory transactions

• Discovered expired or damaged inventory items not properly accounted for

Improving quality involves setting clear standards, continuous monitoring, feedback mechanisms, and employee training.

• Establish clear quality standards and guidelines

• Implement regular quality checks and audits

• Collect feedback from customers and employees

• Provide training and development opportunities for staff

• Use quality improvement tools like Six Sigma or Lean methodologies

Following guidelines involves understanding, implementing, and adhering to established rules and procedures.

• Read and familiarize yourself with the guidelines thoroughly

• Ask for clarification if any part of the guidelines is unclear

• Implement the guidelines in your work or tasks

• Regularly review and update your knowledge of the guidelines

• Seek feedback on your adherence to the guidelines

GMP principles are guidelines for ensuring quality and safety in the manufacturing process.

• GMP stands for Good Manufacturing Practices

• GMP principles include maintaining a clean and hygienic manufacturing environment, proper documentation and record-keeping, and ensuring the quality of raw materials and finished products

• Examples of GMP principles in action include regular equipment maintenance, employee training on proper manufacturing procedures, and thorough testing of produ...read more

Area classification under rlaf refers to the categorization of different areas within a warehouse based on their risk level and fire protection requirements.

• Areas are classified as high, medium, or low risk based on factors such as the type of materials stored, presence of flammable substances, and proximity to ignition sources.

• High-risk areas may include storage areas for flammable liquids or gases, while low-risk areas may include office spaces or break rooms.

• Each classific...read more

21 CFR refers to the Code of Federal Regulations Title 21, which contains regulations related to food and drugs in the United States.

• 21 CFR is a set of regulations established by the Food and Drug Administration (FDA) in the United States.

• It covers regulations related to food, drugs, medical devices, cosmetics, and more.

• Compliance with 21 CFR is mandatory for companies operating in the food and drug industries.

• Examples of regulations under 21 CFR include Good Manufacturing Pr...read more

I have extensive experience in leading a section, managing tasks, and ensuring team success.

• Led a team of 15 employees in a retail store section

• Managed inventory, schedules, and customer service in the section

• Implemented new strategies to increase section sales by 20%

• Received Employee of the Month for exceptional leadership in the section

I have a Bachelor's degree in Business Administration from XYZ University.

• Bachelor's degree in Business Administration

• XYZ University

DCS is used for continuous control of complex processes in industries, while PLC is used for discrete control of machinery and equipment.

• DCS is typically used in industries such as oil and gas, power plants, and chemical plants for continuous control of processes.

• PLC is commonly used in manufacturing industries for discrete control of machinery and equipment.

• DCS allows for centralized control of multiple control loops, while PLC is more decentralized and used for specific tas...read more

Yes, I am okay with a 20% hike.

• I am happy with the offer and appreciate the increase in salary.

• I believe my skills and experience justify the hike.

• I am excited to continue contributing to the company's success.

• I am open to discussing any additional benefits or opportunities.

Calibration of instruments is the process of adjusting and verifying the accuracy of measuring equipment.

• Calibration ensures that instruments provide accurate and reliable measurements.

• It involves comparing the readings of the instrument to a known standard.

• Calibration should be done regularly to maintain accuracy.

• Examples of instruments that require calibration include thermometers, pressure gauges, and scales.

Warehouse role involves managing inventory, receiving and dispatching goods, and ensuring efficient storage and retrieval.

• Managing inventory levels and ensuring stock availability

• Receiving and dispatching goods accurately and efficiently

• Organizing and maintaining the warehouse space

• Ensuring compliance with safety and security regulations

• Collaborating with other departments to optimize supply chain processes

Maintaining cleanliness in all areas of the warehouse is essential for safety and efficiency.

• Regularly sweep and mop floors to remove debris and spills

• Empty trash bins and recycling containers daily

• Clean and sanitize restrooms and break areas regularly

• Organize and declutter storage shelves and racks

• Implement a schedule for deep cleaning tasks such as dusting and window washing