Pfizer Executive Research Trainee Interview Questions, Process, and Tips

Water solid compound is ice.

• Water solid compound is formed when water freezes.

• The solid form of water is known as ice.

• Ice has a crystalline structure and a lower density than liquid water.

• Ice can exist in different forms, such as ice cubes, snowflakes, or glaciers.

Compounds that can be analyzed using HPLC, GC, and MC.

• Polar compounds are suitable for HPLC analysis.

• Non-polar compounds are suitable for GC analysis.

• Compounds that are thermally stable can be analyzed using MC.

• Examples of compounds suitable for all three techniques include caffeine and aspirin.

SAP activity refers to the use of SAP software for business operations and management.

• SAP activity involves using SAP software for various business functions such as finance, human resources, supply chain management, and customer relationship management.

• It helps organizations streamline their processes, improve efficiency, and make data-driven decisions.

• Examples of SAP activity include creating financial reports, manag...read more

pH activity refers to the measurement of acidity or alkalinity of a solution.

• pH activity is measured on a scale of 0-14, with 7 being neutral, below 7 being acidic, and above 7 being alkaline

• It is important in various fields such as chemistry, biology, and environmental science

• For example, pH activity is used to determine the acidity of soil for agriculture, the pH of water for aquatic life, and the pH of blood for med

The pH value decreases when acid is added and increases when alkali is added.

• Acids release hydrogen ions (H+) when dissolved in water, which increases the concentration of H+ ions and lowers the pH value.

• Alkalis release hydroxide ions (OH-) when dissolved in water, which decreases the concentration of H+ ions and raises the pH value.

• The pH scale ranges from 0 to 14, with 7 being neutral. Values below 7 are acidic, and ...read more

Chemical reaction between sodium and chlorine

• Sodium (Na) reacts with chlorine (Cl) to form sodium chloride (NaCl)

• The reaction is exothermic and releases energy in the form of heat and light

• The balanced chemical equation is 2Na + Cl2 -> 2NaCl

Mass spectrometry is a technique used to identify and quantify molecules based on their mass-to-charge ratio.

• Electrospray ionization (ESI)

• Matrix-assisted laser desorption/ionization (MALDI)

• Gas chromatography-mass spectrometry (GC-MS)

• Liquid chromatography-mass spectrometry (LC-MS)

• Time-of-flight mass spectrometry (TOF-MS)

UV spectrometry is a technique that measures the absorption or transmission of ultraviolet light by a sample.

• UV spectrometry is based on the principle that different molecules absorb UV light at specific wavelengths.

• It is commonly used in analytical chemistry to determine the concentration of a substance in a sample.

• UV spectrometry can be used to analyze the purity of a compound or identify unknown substances.

• The instr...read more

To prepare 0.1 N HCl and NaOH, you need to calculate the required amount of the respective chemicals and dilute them in water.

• Calculate the molar mass of HCl and NaOH

• Determine the volume of solution needed

• Use the formula: Normality (N) = (Number of equivalents / Volume of solution in liters)

• For 0.1 N HCl, calculate the number of equivalents of HCl and dilute it to the desired volume

• For NaOH, calculate the number of equ...read more

Quality assurance is the process of ensuring that products or services meet the desired level of quality.

• It involves establishing standards and procedures to ensure that products or services meet those standards.

• It includes monitoring and evaluating the quality of products or services to identify areas for improvement.

• It also involves taking corrective action when necessary to address quality issues.

• Examples include co...read more

Recall definitions

• Recall: the ability to retrieve information from memory

• Definition: a statement that explains the meaning of a word or phrase

• Research: the systematic investigation into and study of materials and sources in order to establish facts and reach new conclusions

• Associate: a person who works with others towards a common goal

• Hypothesis: a proposed explanation for a phenomenon

• Experiment: a scientific procedure...read more

The type of HPLC used depends on the specific research requirements and objectives.

• There are several types of HPLC systems available, including reverse phase, normal phase, ion exchange, size exclusion, and affinity chromatography.

• The choice of HPLC system depends on the properties of the analyte, such as polarity, size, charge, and affinity.

• For example, reverse phase HPLC is commonly used for the separation of nonpola...read more

UV detectors and HPLC detectors are used in research to analyze and quantify substances.

• UV detectors are commonly used in UV-visible spectroscopy to measure the absorption of light by a sample at different wavelengths.

• HPLC detectors are used in high-performance liquid chromatography to detect and quantify the components of a mixture.

• Common types of UV detectors include diode array detectors (DAD) and photodiode array d...read more

Matrix in MALDI MS system is a substance used to assist in ionization of the sample for analysis.

• Matrix is a substance that absorbs energy from the laser and transfers it to the sample, causing ionization.

• The choice of matrix depends on the type of sample being analyzed.

• Common matrices include alpha-cyano-4-hydroxycinnamic acid (CHCA) and sinapinic acid (SA).

Water content mechanism can be found through various methods and is important for various reasons.

• Water content can be measured through techniques such as gravimetric analysis, Karl Fischer titration, and moisture analyzers.

• Water content is important in industries such as food, pharmaceuticals, and cosmetics to ensure product quality and stability.

• Water content is also important in environmental studies to understand t...read more

Developing HPLC methods involves selecting appropriate columns and optimizing parameters.

• Choose a suitable column based on the analyte's properties and the separation goal.

• Optimize parameters such as mobile phase composition, flow rate, and temperature.

• Validate the method by assessing its selectivity, sensitivity, accuracy, and precision.

• Common column types include C18, C8, and phenyl.

• Other factors to consider include ...read more

Carbon loading in column refers to the amount of carbon used in the stationary phase of a chromatography column. Endcapping is a process to block the remaining silanol groups on the surface of the stationary phase.

• Carbon loading is typically expressed as a percentage of the total weight of the stationary phase.

• Higher carbon loading can improve the selectivity and retention of certain analytes.

• Endcapping is important to...read more

Seeking new challenges and opportunities for growth.

• Desire for new challenges and opportunities for growth

• Seeking a more stimulating work environment

• Looking to expand skill set and knowledge

• Company restructuring or downsizing

• Relocation to a new area