Rapture Biotech International (P) Research Intern Interview Questions and Answers

Q1. About NGS and Rt PCR
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Q2. Previous experience
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Assignment will be considered by online based on the professional behaviour.

Q1. Related to technical
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Q2. What is HPLC and how it works
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HPLC is a high-performance liquid chromatography technique used to separate, identify, and quantify components in a mixture.
• HPLC involves a sample being dissolved in a solvent and passed through a column packed with a stationary phase material.

• Different components in the sample interact differently with the stationary phase, leading to separation based on their properties.

• The separated components are detected and quant...read more
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Q1. General question
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Q1. Process related
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Q1. How to handle and quench pyrophoric chemical in reaction.
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Pyrophoric chemicals can be handled and quenched by using inert gases, specialized containers, and proper disposal methods.
• Use inert gases such as nitrogen or argon to displace air and prevent ignition.

• Store and handle pyrophoric chemicals in specialized containers such as air-tight glass ampoules or sealed metal containers.

• Dispose of pyrophoric chemicals properly by contacting a hazardous waste disposal company.

• Exampl...read more
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Q2. Name reactions based on palladium chemistry and copper chemistry
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Palladium and copper chemistry are widely used in organic synthesis. Some important reactions include Suzuki coupling, Heck reaction, Sonogashira coupling, and Ullmann reaction.
• Suzuki coupling: cross-coupling reaction between an organoboron compound and an organic halide or triflate catalyzed by a palladium complex

• Heck reaction: coupling of an aryl or vinyl halide with an alkene in the presence of a palladium catalyst

• S...read more
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Q3. Different oxidising and reducing agent for ester reduction,cyano reduction, alchol oxidation
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Different oxidising and reducing agents used for ester reduction, cyano reduction, and alcohol oxidation.
• Ester reduction: Lithium aluminum hydride (LiAlH4), sodium borohydride (NaBH4), diisobutylaluminum hydride (DIBAL-H)

• Cyano reduction: Lithium aluminum hydride (LiAlH4), sodium borohydride (NaBH4)

• Alcohol oxidation: Chromium trioxide (CrO3), potassium permanganate (KMnO4), Jones reagent (CrO3/H2SO4)
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Q4. Indole, oxazole and isoxazole synthesis route
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30 min containing varieties of test

Q1. Analytical instruments
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Q2. Chemistry of indicator
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Indicators are substances that change color in response to changes in pH levels, helping to determine the acidity or alkalinity of a solution.
• Indicators are typically weak acids or bases that dissociate in water and change color based on the concentration of H+ ions.

• Common indicators include phenolphthalein, litmus, and bromothymol blue.

• The color change of an indicator is due to a shift in the equilibrium between the a...read more
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Q1. Quality assurance and computer system validation with QC instruments handling with calibrations
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Q2. Stability chambers qualification and calibrations for HPLC, FTIR, analytical balance, KF auto titrator, Quality management system its like ccf, incident, deviation, error ratification, abnormal events
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Q3. Qms systems and calibrations and internal department co-ordinance
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