10+ TCS Interview Questions and Answers

pH meter is calibrated with five standards to ensure accuracy and reliability of the readings.

• Calibration with multiple standards helps to detect any errors or inconsistencies in the readings.

• Different standards cover a range of pH values, allowing for a more comprehensive calibration.

• Using multiple standards also helps to account for any changes in the electrode over time.

• The five standard solution usually includes pH 4, 7, 9, 10, and 12.

• Calibration with fewer standards may ...read more

AQL sampling is a statistical method used in quality control to determine the acceptability of a product batch.

• AQL stands for Acceptable Quality Limit

• It involves randomly selecting a sample of products from a batch and inspecting them for defects

• AQL limits are predetermined levels of defects that are considered acceptable in a batch

• If the number of defects found in the sample exceeds the AQL limit, the entire batch may be rejected

Detectors are used in HPLC to detect and quantify the separated components of a sample.

• Detectors measure the amount of analyte passing through the column.

• Common types of detectors include UV-Vis, fluorescence, and mass spectrometry.

• UV-Vis detectors measure absorbance of light by the analyte.

• Fluorescence detectors measure the emission of light by the analyte.

• Mass spectrometry detectors measure the mass-to-charge ratio of the analyte.

• Detectors can be selective or non-selective ...read more

Sampling is the process of selecting a subset of individuals from a larger population to represent the whole.

• Define the population you want to study

• Choose a sampling method (random, stratified, cluster, etc.)

• Determine the sample size

• Select the sample

• Collect data from the sample

• Analyze the data to draw conclusions

Guidelines for stability study

• Stability studies are conducted to determine the shelf life of a product

• The study should include testing of physical, chemical, and microbiological properties

• The study should be conducted at different temperatures and humidity levels

• The study should be conducted on different batches of the product

• The study should be conducted for a duration that is representative of the intended shelf life

• The study should follow guidelines set by regulatory agenc...read more

Deviation refers to the act of departing from an established course or norm.

• Deviation can occur in various contexts such as project management, statistics, and navigation.

• In project management, deviation refers to a divergence from the planned schedule or budget.

• In statistics, deviation is a measure of how spread out the values in a data set are from the mean.

• In navigation, deviation is the error in a magnetic compass reading caused by local magnetic fields.

Calibration of spectrophotometer is a process of adjusting the instrument to ensure accurate and precise measurements.

• Calibration involves comparing the readings of the spectrophotometer to a known standard

• Adjustments are made to the instrument to ensure it is reading accurately

• Calibration should be performed regularly to maintain accuracy

• Examples of standards used for calibration include NIST traceable standards and certified reference materials

Calibration of instruments is essential for accurate measurements and reliable results.

• Calibration ensures that instruments are accurate and reliable

• It involves comparing measurements taken by the instrument to a known standard

• Adjustments are made to the instrument to bring it into alignment with the standard

• Calibration should be performed regularly to maintain accuracy

• Examples of instruments that require calibration include thermometers, scales, and pH meters

OOS in dissolution test refers to an out-of-specification result in the dissolution test.

• OOS can occur due to various reasons such as improper sample preparation, incorrect testing conditions, or instrument malfunction.

• It is important to investigate the root cause of OOS and take corrective actions to prevent it from happening in the future.

• Examples of corrective actions include retesting the sample, adjusting testing conditions, or recalibrating the instrument.

• OOS results ca...read more