10+ Highlands Info Tech Interview Questions and Answers

System suitability parameters are criteria used to ensure that an analytical method is suitable for its intended purpose.

• System suitability parameters include resolution, peak symmetry, retention time, and tailing factor.

• These parameters are used to assess the performance of an analytical method and ensure reliable and accurate results.

• For example, in chromatography, system suitability parameters are used to evaluate the quality of the separation and detection of analytes.

There are two main types of columns used in chromatography: packed columns and capillary columns.

• Packed columns are filled with a stationary phase material, such as silica or polymer beads.

• Capillary columns have a thin film coating on the inner surface, which serves as the stationary phase.

• Examples include gas chromatography columns, liquid chromatography columns, and ion exchange columns.

Reasons for RSD failures include improper electrode placement, inadequate stimulation parameters, and psychological factors.

• Improper electrode placement can lead to ineffective treatment.

• Inadequate stimulation parameters may not provide sufficient pain relief.

• Psychological factors such as anxiety or depression can impact the effectiveness of RSD treatment.

Empower3 software uses various integration methods and tools for data analysis.

• Empower3 software offers integration methods such as peak detection, peak integration, and peak area calculation.

• Tools like Empower 3 Chromatography Data Software are commonly used for integration in chromatography analysis.

• Integration methods in Empower3 software help in accurately quantifying compounds in samples.

• Empower3 software allows for customization of integration parameters to suit specifi...read more

The range of pH values is from 0 to 14, with 7 being neutral.

• pH values below 7 are acidic, with 0 being the most acidic

• pH values above 7 are alkaline or basic, with 14 being the most basic

• A pH of 7 is considered neutral, neither acidic nor basic

Calibration parameters for HPLC include wavelength accuracy, linearity, resolution, and peak symmetry.

• Wavelength accuracy: Ensuring the detector is accurately measuring the wavelength of the sample.

• Linearity: Verifying that the detector response is linear over a range of concentrations.

• Resolution: Assessing the ability of the HPLC system to separate peaks of interest.

• Peak symmetry: Checking the symmetry of peaks to ensure accurate quantification.

OOS investigation procedure involves identifying, documenting, and resolving deviations in quality control processes.

• Initiate investigation promptly upon observing an OOS result

• Document all relevant information including sample details, testing procedures, and environmental conditions

• Conduct root cause analysis to determine the reason for the OOS result

• Implement corrective and preventive actions to address the root cause

• Review and approve investigation report before closing t...read more

Deviation in quality control refers to a departure from standard procedures or specifications. There are two main types of deviations - major and minor.

• Deviation is a departure from standard procedures or specifications

• Major deviations are significant and can impact product quality or safety

• Minor deviations are less significant and may not impact product quality or safety

• Examples of deviations include equipment malfunction, human error, or environmental factors

Calibration procedure involves setting up and adjusting equipment to ensure accurate measurements.

• Calibration involves comparing measurements of two instruments, one with a known magnitude and the other with unknown magnitude.

• Parameters for calibration include temperature, pressure, voltage, etc.

• Calibration procedures should be documented and followed regularly to maintain accuracy.

• Examples of calibration parameters: zero point calibration, span calibration, linearity calibra...read more

Yes, I am currently handling Out of Trend (OOT) investigations in my role as QC Executive.

• Yes, I have experience in identifying OOT results and conducting thorough investigations to determine the root cause.

• I have worked on implementing corrective and preventive actions to prevent future OOT occurrences.

• I have also collaborated with cross-functional teams to address OOT issues and ensure compliance with regulatory requirements.

HPLC uses a variety of lamps depending on the application.

• UV-Vis lamps are commonly used for detecting analytes in HPLC

• Fluorescence lamps are used for detecting fluorescent analytes

• Pulsed amperometric detection (PAD) uses a gold electrode and a mercury lamp

• Diode array detectors (DAD) use a deuterium lamp and a tungsten lamp

• The type of lamp used depends on the specific HPLC application

There are various types of training that can be provided to employees.

• On-the-job training

• Classroom training

• Online training

• Simulation training

• Mentoring and coaching

• Cross-training

• Team training

• Leadership training

Validations are used to ensure that a product or process meets the required standards and specifications.

• There are different types of validations such as process validation, equipment validation, method validation, and cleaning validation.

• Process validation ensures that a manufacturing process consistently produces a product that meets its specifications.

• Equipment validation ensures that equipment used in the manufacturing process is working correctly and producing accurate r...read more

Handling a hydrogen reactor requires proper training, safety precautions, and monitoring.

• Ensure all personnel are properly trained in handling hydrogen and reactor operations

• Implement strict safety protocols to prevent accidents or leaks

• Regularly monitor reactor performance and hydrogen levels to ensure safe operation

• Have emergency response plans in place in case of any incidents

• Consider using automated systems for better control and monitoring