Centaur Pharmaceuticals QC Executive Interview Questions and Answers

Q1. HPLC related all question
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Q1. What is R. S in HPLC?
Ans. 
R. S in HPLC stands for Relative Standard Deviation.
• R. S is a measure of the precision or reproducibility of an HPLC method.

• It is calculated by dividing the standard deviation of peak areas by the average peak area and multiplying by 100.

• R. S is expressed as a percentage and indicates the variability of peak areas in replicate injections.

• A lower R. S value indicates higher precision and better method performance.

• For ex...read more
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Q2. What is assay by HPLC and ehy perform?
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Assay by HPLC is a technique used to separate, identify, and quantify components in a sample.
• HPLC stands for High-Performance Liquid Chromatography.

• It is commonly used in pharmaceutical and chemical industries for quality control purposes.

• Assay by HPLC involves injecting a sample into a high-pressure liquid chromatography system, where the components are separated based on their interactions with the stationary phase.

• T...read more
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Q3. What is resolution?
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Resolution refers to the ability to distinguish between two separate points or objects in an image or display.
• Resolution is a measure of the level of detail in an image or display.

• It is typically measured in terms of pixels or dots per inch (DPI).

• Higher resolution means more pixels or dots, resulting in a clearer and sharper image.

• Resolution is important in various fields such as photography, video production, and disp...read more
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Q4. How calibration of karl fisher?
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Calibration of Karl Fischer is a process to ensure accuracy and reliability of the moisture determination method.
• Calibration involves verifying the performance of the Karl Fischer titration system.

• It includes checking the accuracy of the reagents, electrodes, and the instrument itself.

• Calibration is typically done using standard solutions with known moisture content.

• The instrument readings are compared to the expected ...read more
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Q5. How calibration of HPLC?
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Calibration of HPLC involves verifying the accuracy and precision of the instrument by comparing the results obtained with known standards.
• Calibration of HPLC is essential to ensure accurate and reliable results.

• It involves preparing a series of standard solutions with known concentrations of analytes.

• These standard solutions are then injected into the HPLC system and the peak areas or heights are measured.

• The obtained...read more
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Q6. How prepared 1.0 N NaoH solution?
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To prepare a 1.0 N NaOH solution, dissolve 40.0 g of NaOH in enough water to make 1 liter of solution.
• To prepare a 1.0 N NaOH solution, you need to know the molar mass of NaOH (40.0 g/mol).

• Calculate the number of moles of NaOH required using the formula: moles = N x volume (in liters).

• For a 1.0 N solution, the number of moles of NaOH is equal to the desired concentration (1.0 mol/L).

• Weigh 40.0 g of NaOH using a balance...read more
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Q7. What is molecular weight of HNO3?
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The molecular weight of HNO3 is 63.01 g/mol.
• The molecular weight of a compound is the sum of the atomic weights of all the atoms in its chemical formula.

• For HNO3, the atomic weight of hydrogen (H) is 1.01 g/mol, nitrogen (N) is 14.01 g/mol, and oxygen (O) is 16.00 g/mol.

• Multiplying the atomic weights by the number of atoms in the formula (1 hydrogen, 1 nitrogen, and 3 oxygen) and summing them gives the molecular weight
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Q8. What is molecular weight of ACETIC ACID?
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The molecular weight of acetic acid is 60.052 g/mol.
• The molecular weight of a compound is the sum of the atomic weights of all the atoms in its chemical formula.

• The chemical formula of acetic acid is CH3COOH.

• The atomic weights of carbon (C), hydrogen (H), and oxygen (O) are 12.01 g/mol, 1.008 g/mol, and 16.00 g/mol respectively.

• Calculating the molecular weight of acetic acid: (12.01 * 2) + (1.008 * 4) + 16.00 + 1.008 =
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Q9. Did you now about T. L. C crometography?
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Q1. Why you leave your present company
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Q2. What is your expectations
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Q1. How many months notice period
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Q1. Phone call interview, where he initially told me to introduce myself, later he asked about the basic questions on microbiology 1. What is microbiology 2. How you explain me about the microbiology 3. Exampl...read more
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Q1. 1. Self-introduction 2. 60% questions asked was about my academic project, so be thorough with your project knowledge 3. Questions related to skills which are mentioned on my CV
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Q2. He explained about the job role, work timing and all
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HPLC related questions

Q1. What is a HPLC principle ?
Ans. 
HPLC principle stands for High Performance Liquid Chromatography, a technique used to separate, identify, and quantify components in a mixture.
• HPLC involves the use of a liquid mobile phase and a solid stationary phase to separate compounds based on their interactions with the stationary phase.

• It is commonly used in pharmaceutical, environmental, and food industries for quality control purposes.

• The principle behind HPL...read more
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Q2. What is Role of pka?
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PKA, or protein kinase A, is an enzyme that plays a crucial role in regulating various cellular processes by phosphorylating target proteins.
• PKA is a type of enzyme known as a protein kinase, which adds phosphate groups to target proteins.

• It is involved in regulating processes such as metabolism, gene expression, cell growth, and cell division.

• PKA is activated by cyclic AMP (cAMP), which is a second messenger that rela...read more
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Q3. What is ICH guidelines part 11
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Q1. Why would you choose our company
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Q1. Regarding analytical chemistry
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Q2. 1) about periodic table 2)what is pH 3)Molarity,Normality ,and etc 4)spectroscopy,HPLC,Chromatography
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Q1. Self introduction
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Q2. About microbiology basics
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