70+ QC Officer Interview Questions and Answers

As a QC Officer, my job responsibilities include sampling and testing of raw materials and finished goods using instruments like GC and HPLC. I follow GDP, GMP, GLP, and ensure data integrity. I also perform monthly calibration and troubleshoot instruments.

• Sampling and testing of raw materials and finished goods

• Handling instruments like GC and HPLC

• Following GDP, GMP, GLP, and ensuring data integrity

• Performing monthly calibration of instruments

• Troubleshooting instruments like ...read more

pH is a measure of acidity or alkalinity. UV spectroscopy is based on the absorption of UV light by molecules. Solutions can be prepared in various concentrations like normal, molar, ppm, ppb. Chemistry is the study of matter and its properties. Molality, molarity, and normality are concentration units in chemistry.

• pH measures the concentration of hydrogen ions in a solution, indicating its acidity or alkalinity.

• UV spectroscopy involves measuring the absorption of ultraviolet...read more

The amount of air filtered by a laminar Hepa filter depends on its size and airflow rate.

• The air filtration capacity of a laminar Hepa filter is measured in terms of its Clean Air Delivery Rate (CADR).

• CADR is typically expressed in cubic feet per minute (CFM) or cubic meters per hour (m³/h).

• The CADR of a laminar Hepa filter can vary depending on its dimensions and the fan speed or airflow rate.

• For example, a small laminar Hepa filter with a CADR of 100 CFM can filter 100 cubi...read more

Cu acceptance criteria as per IP, B.P and USP pharmacopoeia.

• Copper acceptance criteria varies slightly between IP, B.P and USP pharmacopoeia.

• IP and B.P specify a minimum purity of 99.5% copper, while USP specifies a minimum purity of 99.0% copper.

• All three pharmacopoeias specify limits for impurities such as lead, iron, zinc, and nickel.

• For example, IP and B.P limit lead to 0.005%, while USP limits lead to 0.002%.

• The pharmacopoeias also specify limits for other parameters suc...read more

Answering questions related to GC and preparation of 1.0N solution of NaOH

• GC stands for Gas Chromatography and is used to separate and analyze compounds in a mixture

• The principle of GC is based on the partitioning of the sample between a stationary phase and a mobile phase

• Precautions of GC include avoiding contamination, using proper sample preparation techniques, and ensuring proper calibration of the instrument

• To prepare a 1.0N solution of NaOH, dissolve 40g of NaOH in 1 li...read more

The size of TLC capillary varies depending on the specific application and manufacturer.

• The size of TLC capillary can range from 0.1 mm to 0.5 mm in diameter.

• The length of TLC capillary can vary from a few centimeters to several meters.

• Different capillary sizes are used for different types of TLC analyses, such as normal phase or reverse phase chromatography.

• For example, a common size for normal phase TLC capillary is 0.25 mm in diameter and 10 cm in length.

• The size of the ca...read more

The interview questions are related to chemistry and involve topics like neutralization reaction, pH meter, pH of soil and water, and chemical formulas of caustic acid and sulfuric acid.

• Neutralization reaction is a chemical reaction between an acid and a base that results in the formation of salt and water.

• A pH meter is an electronic device used to measure the acidity or alkalinity of a solution.

• The pH of soil and water varies depending on the location and other factors. For ...read more

Acidity pH range is from 0 to 6.9.

• Acidity is measured on a pH scale from 0 to 14.

• A pH of 7 is neutral, below 7 is acidic, and above 7 is basic.

• Acidity pH range is important in various industries like food, pharmaceuticals, and cosmetics.

• Examples of acidic substances are lemon juice (pH 2), vinegar (pH 3), and stomach acid (pH 1-2).

Dissolution acceptance criteria is the predetermined limit of drug release from a dosage form.

• It is used to ensure the quality and consistency of the drug product.

• It is based on the drug's pharmacokinetics and therapeutic effect.

• It is determined through in vitro dissolution testing.

• Examples include: 80% of drug release within 30 minutes for immediate release tablets.

• Criteria may vary depending on the drug product and regulatory requirements.

CAPA stands for Corrective and Preventive Action. Tablet is a solid dosage form of medication.

• CAPA is a process used to identify and address the root cause of a problem or non-conformance in a product or process.

• Tablet is a solid dosage form of medication that is compressed into a small, flat shape.

• Tablets can be coated or uncoated, and can be designed to release medication immediately or over a period of time.

• Tablets are commonly used to treat a variety of medical conditions...read more

GPT test stands for Generalized Procrustes Analysis test.

• GPT test is a statistical method used to analyze and compare shapes or configurations.

• It is commonly used in fields such as anthropology, biology, and computer vision.

• The test aligns and scales multiple shapes to a common reference shape, allowing for shape comparison and analysis.

• GPT test can be used to study variations in shape, identify patterns, and assess differences between groups.

• It involves superimposing shapes,...read more

Gas chromatography is a technique used to separate and analyze volatile compounds in a mixture.

• Gas chromatography involves the use of a stationary phase and a mobile phase.

• The stationary phase is a solid or liquid coating inside a column, while the mobile phase is a gas.

• The mixture is injected into the column, and as the mobile phase flows through, different compounds interact with the stationary phase at different rates.

• This separation allows for the identification and quant...read more

Various instruments are used in QC such as HPLC, GC, UV-Vis spectrophotometer, FTIR, etc.

• High Performance Liquid Chromatography (HPLC)

• Gas Chromatography (GC)

• Ultraviolet-Visible (UV-Vis) Spectrophotometer

• Fourier Transform Infrared (FTIR) Spectrometer

• Atomic Absorption Spectrophotometer (AAS)

• Karl Fischer Titrator

• pH Meter

• Viscometer

• Melting Point Apparatus

• Refractometer

Oxidation is the loss of electrons and reduction is the gain of electrons.

• Oxidation involves the loss of electrons from an atom or molecule.

• Reduction involves the gain of electrons by an atom or molecule.

• Oxidation and reduction always occur together in a chemical reaction.

• Examples include rusting of iron (oxidation) and photosynthesis (reduction).

pH is a measure of acidity or alkalinity of a solution. It ranges from 0 to 14, with 7 being neutral.

• pH stands for 'potential of hydrogen'

• It is measured on a scale of 0 to 14

• A pH of 7 is neutral, below 7 is acidic, and above 7 is alkaline

• pH can be measured using pH paper, pH meter, or indicators like litmus paper

• Examples of pH values: lemon juice (pH 2), water (pH 7), baking soda (pH 9)

IS code stands for Indian Standard code and is a set of standards established by the Bureau of Indian Standards (BIS) for various products and services.

• IS 456:2000 - Code of practice for plain and reinforced concrete

• IS 2062:2011 - Specification of steel for general structural purposes

• IS 1343:2012 - Code of practice for prestressed concrete

• IS 1608:2005 - Mechanical testing of metals

• IS 302-2-24:1992 - Safety of household and similar electrical appliances

• IS 539:2001 - Method of ...read more

GC stands for Gas Chromatography. The principle of GC is based on the separation of components of a mixture by their distribution between a stationary phase and a mobile phase.

• GC separates components based on their boiling points and affinity for the stationary phase

• The stationary phase can be a solid or a liquid coated on a solid support

• The mobile phase is usually an inert gas such as helium or nitrogen

• The sample is injected into the GC column and is vaporized by the high te...read more

I prioritize based on urgency, assess available information, consult with team if needed, and make a quick decision.

• Prioritize based on urgency of the situation

• Assess available information quickly

• Consult with team members if needed

• Make a quick decision based on the information gathered

SST parameters and types, and difference between HPLC and UPLC.

• SST parameters include glucose, electrolytes, liver enzymes, and more.

• Types of SST include plain, gel, and clot activator.

• HPLC uses high pressure to separate compounds, while UPLC uses even higher pressure for faster separation.

• HPLC is better for larger molecules, while UPLC is better for smaller molecules.

• Both are used in pharmaceutical and biotech industries for drug development and quality control.

HPLC is a technique used in analytical chemistry to separate, identify, and quantify components in a mixture. Polar and nonpolar refer to the polarity of molecules.

• HPLC stands for High-Performance Liquid Chromatography.

• It is a widely used technique in pharmaceutical, chemical, and food industries.

• HPLC separates components in a mixture based on their interactions with a stationary phase and a mobile phase.

• The stationary phase is a solid or liquid material packed into a column,...read more

UV stands for ultraviolet and is a form of electromagnetic radiation. CGMP stands for current Good Manufacturing Practice.

• UV refers to a type of electromagnetic radiation with a wavelength shorter than that of visible light, commonly used for sterilization and disinfection.

• The principle of UV involves using UV light to disrupt the DNA of microorganisms, preventing them from reproducing.

• CGMP refers to regulations and guidelines set by regulatory agencies to ensure the quality ...read more

Calibration parameters for big HPLC are the specific values used to ensure accurate and precise measurements in high-performance liquid chromatography.

• Calibration parameters include retention time, peak width, peak area, and peak height.

• Retention time is the time it takes for a compound to travel through the HPLC column.

• Peak width is the measure of the width of a peak at its base.

• Peak area is the integrated area under a peak, which represents the amount of a compound present....read more

Cultures refer to the beliefs, customs, practices, and behaviors shared by a group of people.

• Cultures are learned and passed down from generation to generation.

• They include language, religion, food, clothing, art, music, and social norms.

• Cultures vary across different regions, countries, and ethnic groups.

• They influence individuals' values, attitudes, and behaviors.

• Examples of cultures include Western culture, Asian culture, African culture, etc.

Preparation of solutions like Normal, Molar, ppm, ppb, etc.

• Normal solutions are prepared by dissolving a known weight of solute in a known volume of solvent.

• Molar solutions are prepared by dissolving a known number of moles of solute in a known volume of solvent.

• ppm (parts per million) solutions are prepared by dissolving a known weight of solute in a known volume of solvent and expressing the concentration in parts per million.

• ppb (parts per billion) solutions are prepared b...read more

Instruments that require daily and monthly calibration depend on the type of instrument and its usage.

• Instruments used for critical measurements such as pH meters, balances, and thermometers require daily calibration.

• Instruments used for less critical measurements such as pipettes and spectrophotometers require monthly calibration.

• Calibration frequency also depends on the frequency of use and the manufacturer's recommendations.

• Calibration ensures accuracy and reliability of m...read more

HPLC stands for High Performance Liquid Chromatography. Its principle is based on the separation of components in a mixture using a stationary phase and a mobile phase.

• HPLC separates components based on their polarity and size

• It uses a stationary phase (column) and a mobile phase (solvent)

• The sample is injected into the column and the components are separated based on their interaction with the stationary phase and mobile phase

• The separated components are detected and analyze...read more

Aromatic compounds have a cyclic structure with alternating double bonds, while aliphatic compounds have a linear structure without double bonds.

• Aromatic compounds are highly stable and have strong odors.

• Aliphatic compounds are less stable and have weaker odors.

• Examples of aromatic compounds include benzene, toluene, and naphthalene.

• Examples of aliphatic compounds include methane, ethane, and propane.