Acme Generics LLP Quality Control Officer Interview Questions and Answers

HPLC related questions

Q1. What is a HPLC principle ?
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HPLC principle stands for High Performance Liquid Chromatography, a technique used to separate, identify, and quantify components in a mixture.
• HPLC involves the use of a liquid mobile phase and a solid stationary phase to separate compounds based on their interactions with the stationary phase.

• It is commonly used in pharmaceutical, environmental, and food industries for quality control purposes.

• The principle behind HPL...read more
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Q2. What is Role of pka?
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PKA, or protein kinase A, is an enzyme that plays a crucial role in regulating various cellular processes by phosphorylating target proteins.
• PKA is a type of enzyme known as a protein kinase, which adds phosphate groups to target proteins.

• It is involved in regulating processes such as metabolism, gene expression, cell growth, and cell division.

• PKA is activated by cyclic AMP (cAMP), which is a second messenger that rela...read more
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Q3. What is ICH guidelines part 11
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Q1. What are the principles of GCP
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Q2. What are the parameters for method validation
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Parameters for method validation include accuracy, precision, specificity, linearity, range, and robustness.
• Accuracy: how close the measured value is to the true value

• Precision: how reproducible the results are

• Specificity: how well the method measures only the analyte of interest

• Linearity: how well the method produces results that are proportional to the analyte concentration

• Range: the concentration range over which th...read more
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Q1. Questions based on scenarios given to you
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Q1. Tell us about yourself
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I am a detail-oriented Quality Control Officer with a strong background in ensuring product quality and compliance.
• Experienced in conducting quality inspections and audits

• Proficient in using quality control tools and techniques

• Skilled in analyzing data and identifying areas for improvement

• Excellent communication and problem-solving skills

• Ability to work collaboratively in a team environment

• Knowledge of industry regulat...read more
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Q1. What are your salary expectations?
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Q2. Share details of your previous job.
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Q3. Why are you looking for a change?
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Q4. Tell me about yourself.
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Q1. Define the principle of tlc
Ans. 
TLC stands for Thin Layer Chromatography, a technique used to separate and analyze mixtures of chemicals.
• TLC involves a stationary phase (thin layer of adsorbent material) and a mobile phase (solvent).

• The sample mixture is spotted on the TLC plate and the plate is placed in a developing chamber with the mobile phase.

• Different components of the mixture move at different rates on the plate, allowing for separation and id...read more
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Q2. Disintegration and dissolution difference
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Disintegration is the breakdown of a solid dosage form into smaller particles, while dissolution is the process by which a solid substance dissolves in a liquid.
• Disintegration is a physical process, while dissolution is a chemical process.

• Disintegration involves the breaking down of a tablet or capsule into smaller pieces, while dissolution involves the solubilization of the active ingredient.

• Disintegration testing is ...read more
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Q1. What is Quality control
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Quality control is a process used to ensure that products or services meet specific standards and requirements.
• Quality control involves monitoring and testing products or services to identify defects or errors.

• It aims to prevent defects from reaching customers and ensure consistent quality.

• Examples of quality control methods include statistical process control, inspection, and testing.

• Quality control is essential in in...read more
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Q2. How to handle the instrument
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Handle the instrument with care and follow proper procedures
• Always read the instruction manual before using the instrument

• Ensure the instrument is calibrated and maintained regularly

• Use the instrument only for its intended purpose

• Clean the instrument after each use to prevent contamination

• Store the instrument in a safe and secure location when not in use
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Any incident to solve or how to correct kr resolve the problem.

Q1. Blend unifomity calculation and how to select die.
Ans. 
Blend uniformity calculation and die selection for QA/QC Manager role.
• Blend uniformity calculation involves determining the homogeneity of a mixture.

• It is important to select the appropriate die for the blend to ensure consistent tablet weight and hardness.

• Factors to consider when selecting a die include tablet size, shape, and desired release profile.

• Die selection should also take into account the properties of the ac...read more
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Q2. Process and packing validation and related guidline.
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