Senior Medical Reviewer Interview Questions and Answers

The drug works by inhibiting the enzyme responsible for converting angiotensin I to angiotensin II, leading to vasodilation and decreased blood pressure.

• Inhibits angiotensin-converting enzyme (ACE)

• Prevents conversion of angiotensin I to angiotensin II

• Results in vasodilation and decreased blood pressure

Unassessable causality assessment means the relationship between a drug and an adverse event cannot be determined, while conditional causality assessment means the relationship is possible under certain conditions.

• Unassessable causality assessment: unable to determine relationship between drug and adverse event

• Conditional causality assessment: relationship is possible under certain conditions

• Example: Unassessable - patient has multiple medical conditions, making it difficult ...read more

WHO classification of causality assessment is a method used to determine the likelihood of a causal relationship between a drug and an adverse event.

• WHO classification includes categories like certain, probable, possible, unlikely, conditional/unclassified, and unassessable/unclassifiable.

• It helps in determining the strength of evidence linking a drug to an adverse event.

• Example: If a patient develops liver injury after taking a medication and there is a known association bet...read more

Severity refers to the intensity of a medical condition, while seriousness refers to the potential impact or consequences of the condition.

• Severity is the extent to which a medical condition affects an individual's health or quality of life.

• Seriousness is the potential for a medical condition to result in significant harm or complications.

• Severity is often measured on a scale (e.g. mild, moderate, severe), while seriousness considers the potential outcomes of the condition.

• Fo...read more