SAI Life Sciences Senior Research Scientist Interview Questions and Answers

Q1. Named Reactions, Chemical Reagents, Purification and Analytical Techniques.
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Q2. Literature Search.
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Q1. Some basic questions of excel, SQL and Python. Focused more on projects mentioned in CV
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How much you rate in Python and SQL

Q1. Introduce yourself
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Q1. General questions
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Q1. Only salary related discussion
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Q1. Related to experience
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Q1. Formal discussion
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Q1. What's ESI and APCI ?
Ans. 
ESI and APCI are ionization techniques used in mass spectrometry.
• ESI stands for Electrospray Ionization and is used for analyzing polar and charged molecules.

• APCI stands for Atmospheric Pressure Chemical Ionization and is used for analyzing non-polar and neutral molecules.

• Both techniques involve ionizing the sample molecules to create ions that can be analyzed by mass spectrometry.

• ESI is commonly used in proteomics and...read more
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Q2. How do you will select ionisation mode ?
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The ionisation mode is selected based on the type of sample and the information required from the analysis.
• Consider the polarity of the sample and the analyte of interest

• Determine the type of information required from the analysis

• Evaluate the sensitivity and selectivity of different ionisation modes

• Examples: ESI for polar compounds, APCI for non-polar compounds, MALDI for large biomolecules
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Q1. What is sink condition.
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Q2. BCS Classification
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Q3. Outline the OOT and OOS investigation
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OOT and OOS investigations are conducted to determine the root cause of results that are out of specification or out of trend.
• Identify the OOT or OOS result

• Isolate the sample for further testing

• Investigate potential causes such as equipment malfunction or human error

• Document findings and corrective actions taken

• Review and approve investigation report
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Q4. What is the CMC and limits
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Q5. Types of surfactants and limits
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Surfactants are classified into four main types: anionic, cationic, nonionic, and amphoteric, each with specific limits and applications.
• Anionic surfactants have a negatively charged head group and include sulfates, sulfonates, and carboxylates.

• Cationic surfactants have a positively charged head group and are often used as fabric softeners or antimicrobial agents.

• Nonionic surfactants have no charge and are commonly use...read more
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Q6. Brief about RS method development
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RS method development involves creating and optimizing analytical methods for the analysis of raw materials and finished products.
• RS method development includes selecting appropriate analytical techniques based on the properties of the sample.

• It also involves optimizing parameters such as sample preparation, chromatographic conditions, and detection methods.

• Examples of RS method development include developing HPLC meth...read more
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Q1. Saturation solubility as per WHO
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Q2. Contents of SOP
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SOP (Standard Operating Procedure) outlines the steps and guidelines for performing a specific task or process.
• SOPs detail step-by-step instructions

• Include safety precautions and quality control measures

• Should be clear, concise, and easy to follow

• May include diagrams, flowcharts, or checklists

• Regularly reviewed and updated to reflect current best practices
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Q3. Difference between validation and verification
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Validation ensures the right product is being built, while verification ensures the product is being built right.
• Validation confirms that the product meets the customer's requirements and needs.

• Verification ensures that the product is being built according to the specifications and design.

• Validation is about checking if we are building the right product, while verification is about checking if we are building the produ...read more
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Q4. Brief about Dissolution development
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Q5. What is Data integrity
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Data integrity refers to the accuracy, consistency, and reliability of data throughout its lifecycle.
• Ensuring data is accurate and reliable

• Preventing unauthorized access or changes to data

• Maintaining consistency of data across systems

• Implementing data validation processes

• Regularly auditing data to ensure integrity
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Q6. What is cGMP and why it is important
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Q7. Significant changes
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Significant changes refer to major modifications or transformations in a particular aspect or area.
• Significant changes can include shifts in strategy, technology, personnel, or processes.

• Examples of significant changes may include implementing a new software system, restructuring a department, or launching a new product line.

• These changes often require careful planning, communication, and execution to ensure successful
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Q1. Why your changing the organization.
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Q2. Where you want be in 5 years
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Q3. What we can expect from you
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Q4. What your expecting from us
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Q5. Brief about deviation management
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Deviation management involves identifying, documenting, investigating, and resolving any deviations from standard procedures or specifications.
• Deviation management is a process used to address any deviations from established procedures or specifications.

• It involves documenting the deviation, investigating the root cause, and implementing corrective actions to prevent recurrence.

• Examples of deviations include equipment ...read more
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Q6. How you handle incidents
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I handle incidents by remaining calm, assessing the situation, taking appropriate action, and following up to prevent future occurrences.
• Remain calm and composed during the incident

• Assess the situation to determine the severity and necessary actions

• Take appropriate steps to address the incident effectively

• Follow up to analyze the root cause and implement preventive measures

• Communicate effectively with team members and
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Q7. What is your role in investigations
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Q1. Salary negotiation
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Q2. No negotiation direct 30%
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Aptitude. English and Quantitative Aptitude

Q1. Basics of flowcytometry
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Q1. Discussion regarding salary structure
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