Pharmaceutical job Research Scientist Interview Questions and Answers

Q1. Family and education background
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Q2. Willingness to relocate
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Q1. Previous experience principles and techniques
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Q2. Overall technical based
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Q1. Power point presentation of past experience
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Q1. Details about yourself
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Discussion related to previous experience

Q1. Experience discussion
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Experience related questions and some chemistry.

Q1. Experience discussion
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General Organic chemistry questions and API related questions

Q1. Salary discussion
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Q1. 1) self introduction 2) How to develop method for Api to finished products of Assay and Related substances in injectable? 3) column chemistry? 4) method validation 5) ich guidelines
Ans. 
The interview questions cover topics such as self-introduction, developing methods for API to finished products, column chemistry, method validation, and ICH guidelines.
• For self-introduction, briefly talk about your background, education, and relevant experience.

• To develop a method for API to finished products, consider factors such as the desired assay and related substances, analytical techniques, and regulatory requ...read more
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Q2. 6)if mass balance not achieved in forced degradation then whts the possible reason??
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Possible reasons for not achieving mass balance in forced degradation
• Incomplete degradation of the analyte

• Formation of unknown degradation products

• Loss of analyte during sample preparation or analysis

• Inaccurate measurement of sample or standard volumes

• Errors in weighing or dilution of samples

• Contamination of samples or equipment

• Inadequate mixing or homogenization of samples

• Inefficient extraction of analyte from the mat...read more
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Q3. 7) how to develop multimedia dissolution method?
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Multimedia dissolution method can be developed by considering the physicochemical properties of the drug and the media used.
• Select appropriate media that mimic the physiological conditions of the drug's intended site of action

• Determine the solubility and stability of the drug in different media

• Optimize the pH and temperature of the media to enhance drug solubility

• Use appropriate equipment and techniques for sample prep...read more
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Q4. 8) what is sink condition in dissolution?
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Sink condition in dissolution refers to a state where the drug being dissolved is completely solubilized and no further dissolution occurs.
• Sink condition is achieved when the concentration of the drug in the dissolution medium is much lower than its solubility.

• It ensures that the dissolution process is not limited by the drug's solubility but by other factors like diffusion.

• Sink condition is important for accurate and ...read more
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Q5. 9) pka value determination and their role in development?
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pKa value determination and their role in development
• pKa value is a measure of the acidity or basicity of a compound

• It helps in understanding the chemical properties and behavior of a compound

• pKa values are important in drug development as they affect drug solubility, absorption, and stability

• Determining pKa values can aid in optimizing drug formulations and predicting drug-drug interactions
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Q6. 10) Bsc classification and their uses.
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Bsc classification is a system used to categorize and classify living organisms based on their characteristics.
• Bsc classification stands for Biological Species Concept classification.

• It is used to group organisms based on their physical and genetic characteristics.

• The classification system includes Kingdom, Phylum, Class, Order, Family, Genus, and Species.

• Each level of classification is based on specific characteristic...read more
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Q1. Anticancer activity
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Q2. Cancer cell line
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