Pharmaceutical job QC Chemist Interview Questions and Answers

Instrumentation basics refer to the fundamental principles and components of analytical instruments used in chemical analysis.

• Instrumentation basics involve understanding the principles of operation of various analytical instruments such as spectrophotometers, chromatographs, and mass spectrometers.

• It includes knowledge of the components of these instruments, such as detectors, sample introduction systems, and data acq...read more

Instrumentation skills refer to the ability to operate and troubleshoot various laboratory instruments used for analysis.

• Knowledge of different types of analytical instruments such as HPLC, GC-MS, FTIR, UV-Vis spectrophotometer

• Ability to calibrate instruments and perform routine maintenance

• Troubleshooting skills to identify and resolve instrument issues

• Understanding of data analysis software used in conjunction with in...read more

The 3 elements of industrial instrumentation are sensors, transmitters, and controllers.

• Sensors are used to measure physical properties such as temperature, pressure, flow, and level.

• Transmitters convert the sensor signals into a standardized output signal for further processing.

• Controllers receive the standardized signal from transmitters and make adjustments to maintain desired process conditions.

• Example: A temperatu...read more

Reverse phase HPLC is a chromatographic technique used to separate non-polar compounds based on their hydrophobicity.

• Reverse phase HPLC uses a non-polar stationary phase and a polar mobile phase.

• Non-polar compounds elute first, while polar compounds are retained longer.

• It is commonly used in pharmaceutical analysis to determine drug purity and impurities.

• Example: Separation of a mixture of non-polar drugs like benzodia

HPLC is a technique used in chemistry to separate, identify, and quantify components in a mixture. Detector calibration ensures accurate measurement.

• HPLC stands for High-Performance Liquid Chromatography.

• It is used to separate and analyze components in a liquid mixture.

• HPLC utilizes a stationary phase and a mobile phase to separate the components based on their interactions.

• The detector in HPLC measures the concentrati...read more