10+ QA Chemist Interview Questions and Answers

Chemistry is the study of matter and its properties. Organic chemistry deals with carbon-based compounds, while inorganic chemistry deals with non-carbon-based compounds. Analysis is the process of examining a substance to determine its composition or properties, and analytical chemistry is the branch of chemistry that focuses on this process.

• Chemistry is the study of matter and its properties

• Organic chemistry deals with carbon-based compounds, such as hydrocarbons and polyme...read more

Critical parameters for filling and batch manufacturing include line clearance for dispensing and filling.

• Filling parameters include volume, weight, and viscosity of the product.

• Batch manufacturing parameters include mixing time, temperature, and pressure.

• Line clearance for dispensing and filling involves cleaning and sanitizing the equipment and work area.

• Proper documentation and record keeping are essential for ensuring compliance with regulations.

• Examples of critical param...read more

Yes, an RMC plant can run with natural sand having 8% moisture.

• Natural sand with 8% moisture is within acceptable range for RMC production.

• The moisture content can be adjusted during the batching process.

• Proper mixing and curing can still result in high-quality concrete.

• Regular testing and monitoring of moisture levels is important to ensure consistency.

CAPA flow involves identifying deviations, investigating root causes, implementing corrective actions, and verifying effectiveness.

• Identify the deviation or nonconformance

• Investigate the root cause using techniques like 5 Whys, Fishbone diagram

• Implement corrective actions to prevent recurrence

• Verify the effectiveness of the actions taken

• Document the entire CAPA process for future reference

Process validation batches are crucial for ensuring product quality and consistency.

• Process validation batches help to establish that a manufacturing process is capable of consistently producing a product that meets predetermined specifications.

• They are important for ensuring product quality and consistency, as well as for regulatory compliance.

• Validation batches should be representative of routine production batches and should be thoroughly documented and analyzed.

• Examples o...read more

Dissolution time varies for uncoated, film-coated, and enteric-coated tablets based on their formulation and intended release profile.

• Uncoated tablets dissolve quickly, often within 15-30 minutes in gastric fluid.

• Film-coated tablets have a protective layer, typically dissolving in 30-60 minutes.

• Enteric-coated tablets are designed to resist stomach acid, dissolving in the intestine, usually after 1-2 hours.

Paste ration is the ratio of paste to water in a mixture, commonly used in laboratory settings.

• Paste ration is calculated by dividing the weight or volume of paste by the weight or volume of water in a mixture.

• It is often used in quality control processes to ensure consistency and accuracy in formulations.

• For example, a paste ration of 2:1 would mean there are two parts paste for every one part water in the mixture.

Estimation of crude protein process involves determining the amount of protein in a sample using various analytical techniques.

• Crude protein estimation can be done using methods such as Kjeldahl method, Dumas method, and NIR spectroscopy.

• The process involves digesting the sample, converting nitrogen to ammonia, and then measuring the ammonia to calculate protein content.

• Accuracy of the estimation depends on proper sample preparation and calibration of instruments.

• Results are ...read more

Brewing process involves steeping grains in hot water, boiling the resulting liquid, adding hops, cooling and fermenting the mixture.

• Malted grains are steeped in hot water to extract sugars and create wort

• Boiling the wort with hops adds bitterness, flavor, and aroma

• Cooling the mixture and adding yeast starts the fermentation process

• Fermentation converts sugars into alcohol and carbon dioxide

• After fermentation, the beer is conditioned and packaged

Lubricants in tablets enhance flow, prevent sticking, and improve compression during manufacturing.

• Magnesium Stearate: Commonly used, it prevents sticking to equipment.

• Stearic Acid: Acts as a lubricant and can improve tablet hardness.

• Talc: Used for its lubricating properties and to enhance flow.

• Sodium Lauryl Sulfate: A surfactant that also serves as a lubricant.

• Colloidal Silicon Dioxide: Improves flowability and reduces friction.

Crude fiber estimation involves determining the indigestible portion of a sample after digestion with acid and alkali.

• Crude fiber is determined by sequentially digesting a sample with acid and alkali to remove all components except for cellulose, lignin, and other indigestible substances.

• The residue left after digestion is then dried and weighed to calculate the crude fiber content.

• Crude fiber estimation is commonly used in the analysis of animal feed and food products to ass...read more

A tablet is a solid dosage form containing active ingredients and excipients, designed for oral administration.

• Tablets are typically compressed powders that dissolve in the digestive tract.

• They can be coated to enhance stability or mask taste, e.g., enteric-coated tablets.

• Tablets can be formulated for immediate or controlled release of the active ingredient.

• Examples include pain relievers like ibuprofen and vitamins like vitamin C.

Tablet coatings enhance stability, control release, and improve taste, appearance, and patient compliance.

• Sugar Coating: Provides sweetness and a glossy finish; often used in pediatric formulations.

• Film Coating: A thin polymer layer that protects the tablet; examples include HPMC and EC coatings.

• Enteric Coating: Prevents dissolution in the stomach; used for drugs that irritate the stomach lining.

• Controlled Release Coating: Designed to release the drug over an extended period;...read more