CNK & Associates Interview Questions and Answers

S1, S2, and S3 are the limits of dissolution testing.

• S1 is the time at which the first 10% of the drug is dissolved.

• S2 is the time at which 50% of the drug is dissolved.

• S3 is the time at which 90% of the drug is dissolved.

• These limits are used to determine the bioavailability of a drug.

• The limits vary depending on the drug being tested and the regulatory agency involved.

Tablet defects during compression and coating can be caused by various factors, but can be solved through proper equipment maintenance and process control.

• Common defects include capping, lamination, and sticking

• Causes can include improper formulation, inadequate lubrication, and incorrect compression force

• Solutions may involve adjusting process parameters, using different excipients, or replacing worn equipment

• Regular maintenance and calibration of equipment can help prevent ...read more

Atomic Absorption Spectroscopy is a technique used to analyze the concentration of elements in a sample by measuring the absorption of light at specific wavelengths.

• It involves passing a beam of light through a sample containing the element of interest, and measuring the amount of light absorbed by the sample.

• The amount of absorption is directly proportional to the concentration of the element in the sample.

• It is commonly used in environmental analysis, food and beverage test...read more

Particle size distributions refer to the range of sizes of particles in a sample, often represented graphically.

• Particle size distributions show the distribution of particle sizes in a sample, typically ranging from nanometers to millimeters.

• They are commonly represented using histograms, cumulative distribution curves, or other graphical representations.

• Particle size distributions are important in various industries such as pharmaceuticals, food processing, and environmental...read more

Detects observed in coating and compression include color uniformity, thickness consistency, and tablet hardness.

• Color uniformity: Ensure the coating or compression results in consistent color across all tablets.

• Thickness consistency: Check for variations in thickness of the coating or compression layer.

• Tablet hardness: Measure the hardness of the tablets to ensure they meet specifications.

The startup procedure of HPLC involves several steps to ensure proper functioning and accurate results.

• Check the power supply and ensure the instrument is properly connected.

• Turn on the HPLC system and allow it to warm up for a specified period.

• Check the mobile phase and ensure it is prepared correctly.

• Prime the pump by purging air bubbles from the system.

• Load the sample onto the injection port or autosampler.

• Set the desired method parameters such as flow rate, column tempera...read more

CTC expectation and joining time are negotiable based on the offer.

• CTC expectation can vary based on the candidate's experience and skills.

• Joining time can depend on the candidate's notice period and the urgency of the position.

• Both CTC and joining time can be discussed and negotiated during the offer stage.

• The company may have a standard range for CTC and joining time, but it can be flexible for the right candidate.