20+ Vignesh Hitechcity 2 Society Interview Questions and Answers

The necessary checking procedure of a glass lined reactor involves visual inspection, pressure testing, and checking for any signs of corrosion or damage.

• Perform a visual inspection of the glass lining to check for any cracks, chips, or signs of wear.

• Conduct a pressure test to ensure the reactor can withstand the required operating pressure.

• Check for any signs of corrosion on the glass lining, especially in areas exposed to corrosive substances.

• Inspect the reactor's accessori...read more

Calibration is the process of adjusting an instrument to ensure accurate measurements, while validation is the process of ensuring that a method or process produces accurate and reliable results.

• Calibration involves adjusting an instrument to ensure that it provides accurate measurements.

• Validation involves ensuring that a method or process produces accurate and reliable results.

• Calibration is a process that is performed on instruments, while validation is a process that is p...read more

Assay by HPLC is a technique used to separate, identify, and quantify components in a sample.

• HPLC stands for High-Performance Liquid Chromatography.

• It is commonly used in pharmaceutical and chemical industries for quality control purposes.

• Assay by HPLC involves injecting a sample into a high-pressure liquid chromatography system, where the components are separated based on their interactions with the stationary phase.

• The separated components are then detected and quantified u...read more

To prepare a 1.0 N NaOH solution, dissolve 40.0 g of NaOH in enough water to make 1 liter of solution.

• To prepare a 1.0 N NaOH solution, you need to know the molar mass of NaOH (40.0 g/mol).

• Calculate the number of moles of NaOH required using the formula: moles = N x volume (in liters).

• For a 1.0 N solution, the number of moles of NaOH is equal to the desired concentration (1.0 mol/L).

• Weigh 40.0 g of NaOH using a balance.

• Dissolve the weighed NaOH in a small amount of water to m...read more

The molecular weight of HNO3 is 63.01 g/mol.

• The molecular weight of a compound is the sum of the atomic weights of all the atoms in its chemical formula.

• For HNO3, the atomic weight of hydrogen (H) is 1.01 g/mol, nitrogen (N) is 14.01 g/mol, and oxygen (O) is 16.00 g/mol.

• Multiplying the atomic weights by the number of atoms in the formula (1 hydrogen, 1 nitrogen, and 3 oxygen) and summing them gives the molecular weight of HNO3 as 63.01 g/mol.

The molecular weight of acetic acid is 60.052 g/mol.

• The molecular weight of a compound is the sum of the atomic weights of all the atoms in its chemical formula.

• The chemical formula of acetic acid is CH3COOH.

• The atomic weights of carbon (C), hydrogen (H), and oxygen (O) are 12.01 g/mol, 1.008 g/mol, and 16.00 g/mol respectively.

• Calculating the molecular weight of acetic acid: (12.01 * 2) + (1.008 * 4) + 16.00 + 1.008 = 60.052 g/mol.

Calibration of Karl Fischer is a process to ensure accuracy and reliability of the moisture determination method.

• Calibration involves verifying the performance of the Karl Fischer titration system.

• It includes checking the accuracy of the reagents, electrodes, and the instrument itself.

• Calibration is typically done using standard solutions with known moisture content.

• The instrument readings are compared to the expected values to determine any deviations.

• Adjustments are made to...read more

R. S in HPLC stands for Relative Standard Deviation.

• R. S is a measure of the precision or reproducibility of an HPLC method.

• It is calculated by dividing the standard deviation of peak areas by the average peak area and multiplying by 100.

• R. S is expressed as a percentage and indicates the variability of peak areas in replicate injections.

• A lower R. S value indicates higher precision and better method performance.

• For example, if the R. S value is 2%, it means that the peak are...read more

Steam traps are devices used to discharge condensate and non-condensable gases from steam systems.

• There are three main types of steam traps: mechanical, thermostatic, and thermodynamic.

• Mechanical steam traps use a float to open and close a valve.

• Thermostatic steam traps use a temperature-sensitive element to open and close a valve.

• Thermodynamic steam traps use the difference in pressure between steam and condensate to operate a valve.

• Steam traps prevent steam from escaping an...read more

Blend uniformity calculation and die selection for QA/QC Manager role.

• Blend uniformity calculation involves determining the homogeneity of a mixture.

• It is important to select the appropriate die for the blend to ensure consistent tablet weight and hardness.

• Factors to consider when selecting a die include tablet size, shape, and desired release profile.

• Die selection should also take into account the properties of the active ingredient and excipients used in the blend.

• Regular t...read more

Calibration of HPLC involves verifying the accuracy and precision of the instrument by comparing the results obtained with known standards.

• Calibration of HPLC is essential to ensure accurate and reliable results.

• It involves preparing a series of standard solutions with known concentrations of analytes.

• These standard solutions are then injected into the HPLC system and the peak areas or heights are measured.

• The obtained data is used to create a calibration curve, which relates...read more

There are two types of vacuum systems: liquid ring and dry vacuum systems.

• Liquid ring vacuum systems use a liquid as a sealant to create a vacuum.

• Dry vacuum systems use oil-free pumps to create a vacuum.

• Examples of liquid ring vacuum systems include steam jet ejectors and water ring vacuum pumps.

• Examples of dry vacuum systems include scroll pumps and turbo molecular pumps.

Flush bottom valves are used to drain liquids from tanks. Troubleshooting involves identifying and fixing issues with the valve.

• Check for leaks or blockages in the valve

• Inspect the valve for damage or wear and tear

• Ensure that the valve is properly installed and tightened

• Verify that the valve is compatible with the liquid being drained

• Consult manufacturer's instructions or seek expert advice if necessary

U-loop is required in steam lines to prevent thermal expansion and contraction.

• U-loop is a type of expansion joint used in steam lines.

• It is used to absorb the thermal expansion and contraction of the pipe.

• It prevents the pipe from buckling or breaking due to thermal stress.

• U-loop is typically installed in vertical steam lines.

• It is also used in horizontal steam lines where there is limited space for expansion.

• U-loop is designed to accommodate both axial and lateral movement ...read more

The F0 value is calculated by...

• F0 value is calculated using the formula...

• To calculate the F0 value, you need to...

• The F0 value can be determined by...

Maintaining aseptic conditions involves implementing strict hygiene practices and using sterile equipment to prevent contamination.

• Follow proper hand hygiene protocols, including washing hands thoroughly with soap and water or using alcohol-based hand sanitizers.

• Wear appropriate personal protective equipment (PPE) such as gloves, masks, and gowns.

• Ensure the cleanliness and sterility of the production area by regularly cleaning and disinfecting surfaces and equipment.

• Use steri...read more

Resolution refers to the ability to distinguish between two separate points or objects in an image or display.

• Resolution is a measure of the level of detail in an image or display.

• It is typically measured in terms of pixels or dots per inch (DPI).

• Higher resolution means more pixels or dots, resulting in a clearer and sharper image.

• Resolution is important in various fields such as photography, video production, and display technology.

• For example, a high-resolution camera can c...read more

I am looking for a competitive CTC based on my experience, skills, and the industry standards.

• I am seeking a CTC that reflects my qualifications and contributions to the organization

• I am open to negotiation based on the overall compensation package offered

• I have researched industry standards and salary benchmarks to determine a reasonable CTC expectation

Tunnel validation involves checking the integrity and functionality of tunnels for various purposes.

• Check for proper ventilation and lighting inside the tunnel

• Inspect for any signs of water leakage or structural damage

• Test communication systems to ensure connectivity throughout the tunnel

• Verify emergency exits and evacuation procedures

• Conduct regular maintenance and monitoring for safety

Vial washing validation involves ensuring the cleanliness and sterility of vials used in pharmaceutical production.

• Develop a validation protocol outlining the procedures and acceptance criteria for vial washing

• Perform a risk assessment to identify critical control points in the vial washing process

• Conduct studies to validate the effectiveness of the vial washing equipment and process

• Use appropriate analytical methods to test for residues and microbial contamination

• Document al...read more

Quality plays a critical role in ensuring the sterility and safety of products in aseptic areas.

• Ensuring compliance with regulatory requirements for aseptic processing

• Implementing and monitoring aseptic techniques and procedures

• Performing regular environmental monitoring to detect any contamination

• Training personnel on proper aseptic practices

• Investigating and addressing any deviations or failures in aseptic processes

ICH guidelines provide standards for quality in pharmaceuticals.

• ICH stands for International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use.

• The guidelines cover topics such as stability testing, impurities, and analytical validation.

• Adherence to ICH guidelines is often required by regulatory agencies for drug approval.

• Examples of ICH guidelines include Q1A(R2) for stability testing and Q3C(R6) for impurities.

ICH guidelines are a set of international standards for the development, registration, and post-approval of pharmaceutical products.

• ICH guidelines cover topics such as clinical trials, quality control, and safety monitoring.

• Examples of ICH guidelines include E6(R2) Good Clinical Practice, Q9 Quality Risk Management, and M7 Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk.

• The guidelines are developed by the I...read more