Interview Questions and Answers

HATU is used as a coupling reagent in acid amine coupling to form peptide bonds.

• HATU stands for 2-(1H-7-Azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate

• It is a highly efficient coupling reagent used in solid-phase peptide synthesis

• HATU activates carboxylic acids to form reactive intermediates that can react with amines to form peptide bonds

• It is preferred over other coupling reagents like DCC and DIC due to its higher efficiency and lower epimerization rat...read more

Cross coupling reaction involves the formation of a covalent bond between two different molecules or functional groups.

• It is a type of reaction used in organic chemistry to form carbon-carbon, carbon-nitrogen, or carbon-oxygen bonds.

• It involves the use of a catalyst, typically a transition metal, to facilitate the reaction.

• Examples include the Suzuki-Miyaura reaction, the Heck reaction, and the Stille reaction.

• Cross coupling reactions have many applications in the synthesis o...read more

CIS and trance proton pattern in NMR refers to the orientation of protons in a molecule.

• CIS refers to the protons that are on the same side of a double bond or ring in a molecule

• Trans refers to the protons that are on opposite sides of a double bond or ring in a molecule

• The pattern of these protons can be observed in NMR spectroscopy and can provide information about the structure of the molecule

• For example, in a molecule with a double bond, the CIS protons will have a differ...read more

Oxidative coupling reactions involve the formation of a covalent bond between two molecules through the removal of hydrogen atoms.

• Involves the formation of a new covalent bond between two molecules

• Typically involves the removal of hydrogen atoms

• Commonly used in organic synthesis to create complex molecules

• Examples include the Heck reaction and the Wacker process

Scientific knowledge encompasses facts, theories, and principles acquired through systematic study and experimentation.

• Scientific knowledge is based on empirical evidence and is subject to change as new evidence is discovered

• It is built upon the scientific method, which involves making observations, forming hypotheses, conducting experiments, and analyzing data

• Scientific knowledge is used to explain natural phenomena, make predictions, and develop technologies

• Examples include...read more