Aragen Life Sciences R&D Chemist Interview Questions, Process, and Tips

Q1. Define Suzuki coupling reaction
Ans. 
Suzuki coupling reaction is a cross-coupling reaction between an organoboron compound and an organic halide catalyzed by a palladium catalyst.
• Involves the coupling of an organoboron compound with an organic halide

• Catalyzed by a palladium catalyst

• Forms a new carbon-carbon bond

• Widely used in organic synthesis

• Example: Coupling of phenylboronic acid with bromobenzene
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Q2. NMR chemical shift values
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NMR chemical shift values are unique for each type of atom in a molecule and are influenced by surrounding chemical environment.
• Chemical shift values are measured in parts per million (ppm) relative to a standard reference compound.

• Different types of atoms (e.g. hydrogen, carbon) have characteristic chemical shift ranges.

• Chemical shift values can be influenced by factors such as neighboring atoms, functional groups, an
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Q1. Oxidation reduction base
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Q2. Function group interconversion
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Q3. Spectroscopy NMR IR most of q
Ans. 
Spectroscopy techniques NMR and IR are commonly used in chemistry research and analysis.
• NMR (nuclear magnetic resonance) spectroscopy is used to determine the structure and composition of molecules by analyzing their magnetic properties.

• IR (infrared) spectroscopy is used to identify functional groups in molecules by analyzing their absorption of infrared radiation.

• Both techniques are non-destructive and can be used to ...read more
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Q1. What is the role of died mitsnubu reaction?
Ans. 
The Dieckmann condensation or Dieckmann cyclization is a chemical reaction used to form a cyclic molecule from a diester.
• The reaction involves the formation of a cyclic molecule from a diester through intramolecular nucleophilic substitution.

• It is named after German chemist Walter Dieckmann.

• The reaction is commonly used in the synthesis of cyclic ketones and lactones.

• The reaction can be catalyzed by both acids and base...read more
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Q2. What is Buchwald coupling
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Buchwald coupling is a palladium-catalyzed cross-coupling reaction used to form carbon-carbon bonds.
• Buchwald coupling is a type of cross-coupling reaction in organic chemistry.

• It involves the use of a palladium catalyst to form carbon-carbon bonds.

• The reaction typically involves an aryl halide or pseudohalide and an organoboron compound as reactants.

• Buchwald coupling is widely used in the synthesis of pharmaceuticals, ...read more
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