10+ Technology Transfer Executive Interview Questions and Answers

Stop the process immediately and investigate the cause of emulsion formation.

• Stop the agitation and allow the emulsion to settle.

• Analyze the composition of the batch to identify the cause of emulsion formation.

• Adjust the process parameters such as temperature, pH, or mixing speed to prevent emulsion formation in future batches.

• Consider using additives or surfactants to stabilize the emulsion.

• Consult with experts or colleagues for advice on how to prevent emulsion formation.

Basic fundamentals working principles of equipment include understanding its components, operation, maintenance, and safety measures.

• Components: understanding the parts that make up the equipment

• Operation: understanding how the equipment works and how to use it properly

• Maintenance: understanding how to keep the equipment in good working condition

• Safety measures: understanding how to use the equipment safely and prevent accidents

• Example: Basic fundamentals of a computer includ...read more

Crystallization is the formation of crystals from a solution, while precipitation is the formation of solid particles from a solution.

• Crystallization involves the formation of a crystal lattice structure, while precipitation does not.

• Crystallization is a more controlled process, while precipitation can be more random.

• Crystallization is often used in the production of pharmaceuticals, while precipitation is used in wastewater treatment.

• Crystallization can be induced by cooling...read more

Micronization is the process of reducing particle size to micrometer range, while multimill is a type of milling equipment used for size reduction.

• Micronization is used to improve solubility, bioavailability, and stability of drugs.

• Multimill is commonly used in the pharmaceutical industry for granulation and size reduction of materials.

• Micronization can be achieved through various methods such as jet milling, ball milling, and spray drying.

• Multimill operates on the principle ...read more

Bound moisture refers to water molecules that are chemically attached to a substance.

• Bound moisture cannot be removed by simple drying methods.

• It is often found in pharmaceuticals, food products, and other materials.

• Bound moisture can affect the stability and shelf life of a product.

• It is important to measure and control bound moisture levels in manufacturing processes.

Granulation, coating, and compression are processes used in pharmaceutical manufacturing.

• Granulation involves the formation of granules from powder particles to improve flowability and compressibility.

• Coating is the process of applying a thin layer of material to a tablet or capsule to improve appearance, taste, or stability.

• Compression is the process of compressing powder particles into a tablet or capsule form.

• Examples of coatings include enteric coatings, which protect the...read more

Granulation end point is the stage in the granulation process where the desired particle size and moisture content are achieved.

• Granulation end point is determined by monitoring the particle size and moisture content of the granules.

• It is important to reach the granulation end point to ensure the desired product quality.

• The granulation end point can be identified through various methods such as sieve analysis and moisture content measurement.

• Examples of granulation end point ...read more

Retrospective validation is the process of validating a system or process after it has been in use.

• It involves analyzing historical data to ensure that the system or process has been consistently meeting its intended requirements and specifications.

• It is often used when a system or process was not validated before it was put into use.

• Retrospective validation can also be used to identify areas for improvement and to update validation protocols.

• Examples include validating a man...read more

Supac guidelines are FDA's guidance documents for pharmaceutical manufacturers to ensure consistent quality of drug products.

• Supac stands for Scale-up and Post-approval Changes

• Supac guidelines provide recommendations for pharmaceutical manufacturers to ensure consistent quality of drug products

• The guidelines cover various aspects such as manufacturing, packaging, labeling, and testing

• Examples of Supac guidelines include Supac-IR, Supac-MR, Supac-SS, and Supac-SSD

• Supac guideli...read more

There are several classes of solvents, including polar, nonpolar, protic, aprotic, and supercritical fluids.

• Polar solvents dissolve polar compounds and have a dipole moment, such as water and ethanol.

• Nonpolar solvents dissolve nonpolar compounds and lack a dipole moment, such as hexane and benzene.

• Protic solvents have a hydrogen atom attached to an electronegative atom and can donate hydrogen bonds, such as methanol and acetic acid.

• Aprotic solvents lack a hydrogen atom attach...read more

Reynolds number is a dimensionless quantity used to predict fluid flow patterns and turbulence.

• It is used to determine whether a fluid flow is laminar or turbulent

• It is calculated using the fluid velocity, density, viscosity, and characteristic length

• Higher Reynolds number indicates turbulent flow while lower indicates laminar flow

• It is named after Osborne Reynolds, a British physicist and engineer

A device used to extinguish small fires by releasing chemicals or water.

• Fire extinguishers come in different types, such as water, foam, powder, and CO2.

• They are typically found in public buildings, homes, and vehicles.

• Fire extinguishers should be inspected and maintained regularly to ensure they are in working condition.

• They are designed to be used on small fires and should not be used on large or spreading fires.

• The acronym PASS (Pull, Aim, Squeeze, Sweep) is commonly used ...read more

Mesh can be measured by counting the number of openings per inch or centimeter.

• Count the number of openings in a linear inch or centimeter

• Use a mesh gauge to measure the size of the openings

• Measure the thickness of the wire used to make the mesh

• Calculate the open area of the mesh

• Compare the mesh to a standard reference chart

I'm sorry, I need more context. Permits for what?

• Please provide more information about the context of the permits.

• Are you referring to permits for a specific industry or activity?

• Without additional information, I cannot provide an accurate answer.

Micronization is the process of reducing particle size to improve solubility, bioavailability, and stability of drugs.

• Micronization is commonly used in the pharmaceutical industry to improve drug performance.

• It involves reducing the particle size of a drug to less than 10 microns.

• This process can improve the solubility, bioavailability, and stability of drugs.

• Examples of drugs that have been micronized include ibuprofen, naproxen, and danazol.