Senior Research Associate Interview Questions and Answers for Freshers

The role of a particular reagent in a reaction is to initiate, catalyze, or participate in the reaction.

• Reagents can be used to initiate a reaction by providing energy or a catalyst to start the reaction.

• Reagents can also be used to catalyze a reaction by lowering the activation energy required for the reaction to occur.

• Reagents can participate in a reaction by reacting with other molecules to form new products.

• For example, in the reaction between hydrochloric acid and sodium...read more

The final product would depend on the specific reagents used and the reaction conditions.

• The final product could be different in terms of yield, purity, and chemical properties.

• The reaction mechanism and kinetics could also be affected by the change in reagent.

• Examples of changes in reagents could include using a different catalyst or solvent.

• The final product could also be affected by the stoichiometry of the reaction.

• It is important to consider the potential side reactions ...read more

Aldehydes can be converted to alkynes using strong bases and alkyl halides in a two-step process known as the Corey-Fuchs reaction.

• The Corey-Fuchs reaction involves converting an aldehyde to an intermediate alkyne using a phosphonium ylide.

• First, the aldehyde is treated with a phosphonium salt and a strong base to form an alkyne.

• For example, using phenylacetaldehyde with a phosphonium salt can yield phenylacetylene.

• This method is efficient for synthesizing terminal alkynes fr...read more

The Suzuki reaction produces biphenyls as products, with boronic acids and palladium catalysts as key components.

• The Suzuki reaction involves coupling aryl halides with boronic acids.

• Palladium catalysts are commonly used, such as Pd(PPh3)4.

• Byproducts can include unreacted starting materials and biphenyls.

• Example: Coupling phenylboronic acid with bromobenzene yields biphenyl.

I will provide a detailed walkthrough of the Powerpoint presentation.

• Start by introducing the topic and purpose of the presentation

• Outline the main points and structure of the presentation

• Explain each slide in detail, using visuals and data to support key points

• Engage the audience by asking questions and encouraging discussion

• Conclude with a summary and key takeaways

• Offer to answer any questions or provide additional information

NMR values for moisture in DMSO and CDCl3 are crucial for understanding solvent purity and sample conditions.

• DMSO typically shows a peak for water at around 3.3 ppm.

• CDCl3 has a residual water peak around 1.56 ppm.

• The presence of moisture can affect NMR results, indicating solvent quality.

• For accurate NMR analysis, it's essential to minimize moisture in samples.

Drug discovery process involves identifying, designing, testing, and optimizing potential new medications.

• Identification of drug targets through research and analysis

• Designing molecules that interact with the target in a desired way

• Testing the molecules for efficacy, safety, and pharmacokinetics

• Optimizing lead compounds through iterative testing and refinement

• Clinical trials to evaluate the drug's effectiveness and safety in humans

An antibody is a protein produced by the immune system in response to the presence of a specific antigen.

• Antibodies are Y-shaped proteins that bind to antigens, such as viruses or bacteria, to help neutralize them.

• They are produced by B cells in the immune system.

• Antibodies play a crucial role in the immune response by recognizing and targeting foreign substances for destruction.

• Examples of antibodies include IgG, IgM, and IgA.