10+ Research Officer Interview Questions and Answers

The ICH guideline that describes elemental impurities is ICH Q3D.

• ICH Q3D is a guideline developed by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH).

• It provides guidance on the control of elemental impurities in drug products.

• The guideline establishes Permitted Daily Exposures (PDEs) for 24 elemental impurities.

• It outlines the analytical procedures and risk assessment principles for evaluating and controlling eleme...read more

Method development of dissolution involves selecting appropriate dissolution apparatus, media, and conditions to optimize drug release.

• Select appropriate dissolution apparatus based on drug characteristics and dosage form.

• Choose dissolution media that mimics physiological conditions.

• Optimize conditions such as temperature, agitation speed, and sampling time.

• Validate the method by testing for specificity, linearity, accuracy, and precision.

• Consider factors such as sink conditi...read more

Contamination in microbiology lab can be sorted by identifying the source, cleaning the area, and implementing preventive measures.

• Identify the source of contamination

• Clean the affected area thoroughly

• Implement preventive measures such as using sterile equipment and maintaining proper hygiene

• Discard contaminated samples or cultures

• Isolate affected area to prevent further contamination

• Train lab personnel on proper handling and disposal of samples

• Regularly monitor and test for ...read more

Designing a research project to assess the benefits of an educational intervention for teacher pedagogy.

• Identify the target population of teachers and the specific pedagogical skills to be trained.

• Develop a pre-test and post-test to measure the effectiveness of the intervention.

• Randomly assign teachers to either the intervention group or a control group.

• Administer the intervention to the intervention group and no intervention to the control group.

• Collect data on student outco...read more

Sink condition refers to the state where cells stop growing due to depletion of nutrients or accumulation of waste products.

• Sink condition is a common problem in cell culture.

• It can be caused by overgrowth of cells, depletion of nutrients, or accumulation of waste products.

• To maintain sink condition, cells should be subcultured regularly and media should be changed frequently.

• Monitoring cell growth and viability is important to prevent sink condition.

• Adding fresh media or sup...read more

UV inactivation refers to the process of using ultraviolet light to deactivate or kill microorganisms in a sample.

• UV inactivation is a method commonly used in laboratories and water treatment facilities to sterilize samples.

• Ultraviolet light damages the DNA of microorganisms, preventing them from reproducing or causing harm.

• UV inactivation is effective against a wide range of pathogens, including bacteria, viruses, and protozoa.

• Examples of UV inactivation applications include...read more

Saturated solubility is the maximum amount of solute that can dissolve in a solvent at a given temperature, while BCS solubility is the solubility of a drug in a simulated intestinal fluid.

• Saturated solubility is affected by temperature and pressure, while BCS solubility is affected by pH and presence of surfactants.

• Saturated solubility is used to determine the maximum concentration of a solute in a solution, while BCS solubility is used to predict the in vivo performance of ...read more

The most commonly followed chapter for validation is ICH (International Conference on Harmonisation) guidelines.

• ICH guidelines are followed for validation in pharmaceutical industry.

• Validation is important to ensure the accuracy and reliability of research findings.

• Other guidelines such as FDA guidelines may also be followed depending on the specific requirements.

• Validation involves testing and documenting the performance of analytical methods or processes.

• Validation helps to...read more

Column chemistry refers to the study of the chemical processes that occur within a chromatography column.

• Column chemistry involves interactions between the stationary phase and the mobile phase in chromatography.

• It focuses on how compounds are separated based on their chemical properties.

• Understanding column chemistry is crucial for optimizing chromatographic separations.

• Examples include reverse-phase chromatography, ion-exchange chromatography, and size-exclusion chromatogra...read more

Molecular genetics is the study of the structure and function of genes at a molecular level.

• Focuses on DNA, RNA, and protein interactions

• Involves techniques like PCR, DNA sequencing, and gene editing

• Used in research to understand genetic diseases and develop treatments