Syngene International Research Scientist Interview Questions and Answers for Experienced

Q1. All the basic concepts
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Q1. N-alkylation of primary and secondary amines
Ans. 
N-alkylation is a process of adding an alkyl group to a primary or secondary amine.
• N-alkylation can be achieved through various methods such as reductive amination, Gabriel synthesis, and Hoffmann degradation.

• Primary amines can be selectively N-alkylated using alkyl halides and a base, while secondary amines require a more reactive alkylating agent such as an epoxide or an alkyl halide.

• N-alkylation is an important reac...read more
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Q2. NMR values, mitsunobu reaction, and some other named reactions, coupling reactions
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Q1. About my experience in aragen and salary discussions
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Questions where take from msc basics

Q1. Any synthesis done in college explain with mechanism
Ans. 
Synthesized 2-methylcyclohexanol from cyclohexene using acid-catalyzed hydration.
• Started with cyclohexene and added concentrated sulfuric acid to protonate the double bond.

• Water was then added to the reaction mixture, which attacked the carbocation intermediate to form a tertiary alcohol.

• The product was then extracted and purified via distillation.

• 2-methylcyclohexanol was characterized using IR and NMR spectroscopy.
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Q2. Analytical valves, oxidation, reduction
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Q3. Named reactions, molarity, normality
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Q1. About bond, and salary package
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Q1. CIS and trance proton pattern in NMR
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CIS and trance proton pattern in NMR refers to the orientation of protons in a molecule.
• CIS refers to the protons that are on the same side of a double bond or ring in a molecule

• Trans refers to the protons that are on opposite sides of a double bond or ring in a molecule

• The pattern of these protons can be observed in NMR spectroscopy and can provide information about the structure of the molecule

• For example, in a molec...read more
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Q2. Oxidation of alcohol to acid
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Oxidation of alcohol to acid is a chemical reaction that involves the loss of electrons from an alcohol molecule resulting in the formation of a carboxylic acid.
• The oxidation of primary alcohols results in the formation of aldehydes which are further oxidized to carboxylic acids.

• Secondary alcohols are oxidized to ketones which cannot be further oxidized.

• Tertiary alcohols cannot be oxidized to carboxylic acids.

• Common ox...read more
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Q1. Name reactions, quenching pyrophoric reagents, NMR spectroscopy. Oxidation reagents, reduction reagents.
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Q1. Why you are changing? Salary expectation? Ready to relocate? If given offer you will join?
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