Syngene International R&D Chemist Interview Questions and Answers for Freshers

Q1. Define Suzuki coupling reaction
Ans. 
Suzuki coupling reaction is a cross-coupling reaction between an organoboron compound and an organic halide catalyzed by a palladium catalyst.
• Involves the coupling of an organoboron compound with an organic halide

• Catalyzed by a palladium catalyst

• Forms a new carbon-carbon bond

• Widely used in organic synthesis

• Example: Coupling of phenylboronic acid with bromobenzene
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Q2. NMR chemical shift values
Ans. 
NMR chemical shift values are unique for each type of atom in a molecule and are influenced by surrounding chemical environment.
• Chemical shift values are measured in parts per million (ppm) relative to a standard reference compound.

• Different types of atoms (e.g. hydrogen, carbon) have characteristic chemical shift ranges.

• Chemical shift values can be influenced by factors such as neighboring atoms, functional groups, an
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Q1. What is the role of died mitsnubu reaction?
Ans. 
The Dieckmann condensation or Dieckmann cyclization is a chemical reaction used to form a cyclic molecule from a diester.
• The reaction involves the formation of a cyclic molecule from a diester through intramolecular nucleophilic substitution.

• It is named after German chemist Walter Dieckmann.

• The reaction is commonly used in the synthesis of cyclic ketones and lactones.

• The reaction can be catalyzed by both acids and base...read more
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Q2. What is Buchwald coupling
Ans. 
Buchwald coupling is a palladium-catalyzed cross-coupling reaction used to form carbon-carbon bonds.
• Buchwald coupling is a type of cross-coupling reaction in organic chemistry.

• It involves the use of a palladium catalyst to form carbon-carbon bonds.

• The reaction typically involves an aryl halide or pseudohalide and an organoboron compound as reactants.

• Buchwald coupling is widely used in the synthesis of pharmaceuticals, ...read more
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Q1. What is Real World Evidence?
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Q2. How to get frequency counts?
Ans. 
Frequency counts can be obtained by counting the number of occurrences of each unique value in a dataset.
• Use the COUNTIF function in Excel to count occurrences of a specific value in a column

• Use the value_counts() function in Python's pandas library to get frequency counts of unique values in a dataframe column

• Use the table() function in R to get frequency counts of unique values in a vector or dataframe column
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Q1. About your experience
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Q1. CGMP related and GDP and Technical.
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Q1. Qualifications, validations,data integrity
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SQL aptitude questions

Q1. One on one interview on technical
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Q1. Basic questions about self and organisation
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MCQs on critical thinking & basic Maths

I was asked easy level questions to work with Java, SQL, etc.

Q1. No questions as such, just normal discussion
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