Shree Venkatesh International QC Executive Interview Questions and Answers

Q1. Hplc principal and calibration UV principle and calibration
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Q2. What is stability study and why use stability
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Q1. Trouble shooting of HPLC
Ans. 
Troubleshooting of HPLC involves identifying and resolving issues with the high-performance liquid chromatography system.
• Check for leaks in the system and tighten connections if necessary.

• Inspect and clean the columns regularly to ensure optimal performance.

• Calibrate the detector and pump to maintain accuracy of results.

• Troubleshoot error messages on the HPLC software by checking system settings and parameters.

• Consult ...read more
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Q2. Why use caffeine for calibration of HPLC
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Caffeine is used for calibration of HPLC due to its well-defined retention time and peak shape.
• Caffeine has a well-defined retention time, making it easy to identify and calibrate the HPLC system.

• Caffeine produces a sharp and symmetrical peak, which helps in accurately determining the system's performance.

• It is a commonly used compound for calibration in HPLC due to its stability and reproducibility.

• Using caffeine as a...read more
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Q1. Working experience and previous company salary
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Total 30 Questions (15 Aptitude and 15 Technical Questions)

Q1. Any Nameing reaction Mechanism
Ans. 
The Grignard reaction involves the addition of an organomagnesium halide to a carbonyl group.
• The reaction is named after French chemist Victor Grignard.

• It is used to form carbon-carbon bonds and is a key reaction in organic synthesis.

• An example is the synthesis of triphenylmethanol from benzophenone and phenylmagnesium bromide.

• The reaction proceeds through the formation of a Grignard reagent, which then attacks the car...read more
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Q2. What is Titration, What is pH
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Titration is a technique to determine the concentration of a substance in a solution. pH is a measure of acidity or basicity of a solution.
• Titration involves adding a solution of known concentration to a solution of unknown concentration until the reaction is complete.

• pH is measured on a scale of 0-14, with 7 being neutral, below 7 acidic, and above 7 basic.

• Titration can be used to determine the concentration of acids,...read more
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Q1. Waiting For 2 Months
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Q1. What is pH meter , How to calibrate pH meter
Ans. 
A pH meter is a scientific instrument used to measure the acidity or alkalinity of a substance. Calibration ensures accurate readings.
• pH meter measures the concentration of hydrogen ions in a solution

• Calibration involves adjusting the pH meter to known standard solutions

• Regular calibration ensures accurate readings over time
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Q2. Explain the parts of HPLC
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HPLC stands for High Performance Liquid Chromatography, which consists of a pump, injector, column, detector, and integrator.
• HPLC involves a pump to push the liquid solvent through the system.

• It includes an injector to introduce the sample into the mobile phase.

• The column separates the components of the sample based on their interactions with the stationary phase.

• A detector measures the amount of analyte in the eluent.

• ...read more
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Q1. What are the buffer used in HPLC
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Buffers commonly used in HPLC include phosphate buffers, acetate buffers, and citrate buffers.
• Phosphate buffers are commonly used in HPLC for separating acidic compounds.

• Acetate buffers are used for separating basic compounds.

• Citrate buffers are used for separating metal ions.

• Other common buffers used in HPLC include ammonium acetate and ammonium formate.
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Q2. How to calibrate HPLC
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HPLC calibration involves adjusting parameters to ensure accurate and reliable results.
• Prepare standard solutions of known concentrations

• Run the standard solutions through the HPLC system

• Compare the results to expected values and adjust parameters as needed

• Repeat the process until accurate and consistent results are obtained
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