20+ Interview Questions and Answers

Major breakdowns in reactor, centrifuge, and ANFD and their solutions.

• Reactor breakdown: Possible causes include overheating, loss of coolant, or control system failure. Solutions may involve emergency shutdown, cooling measures, or repairs.

• Centrifuge breakdown: Common issues include imbalance, bearing failure, or motor malfunction. Solutions may include recalibration, replacement of faulty parts, or maintenance.

• ANFD breakdown: Problems can arise from clogging, leakage, or ma...read more

Reactors may face various types of problems, and they can be rectified through troubleshooting and maintenance.

• Reactors may face issues such as overheating, leaks, or mechanical failures.

• To rectify these problems, troubleshooting techniques can be used to identify the root cause.

• Maintenance activities like cleaning, repairing, or replacing faulty components can help in resolving the issues.

• Regular inspections and preventive maintenance can prevent problems from occurring in t...read more

Changing mechanical seal pumps and reactors involves several steps and precautions.

• Ensure the pump or reactor is properly shut down and isolated from the power source.

• Drain the fluid from the pump or reactor and relieve any pressure.

• Remove the old mechanical seal carefully, following the manufacturer's instructions.

• Clean the seal chamber and inspect for any damage or wear.

• Install the new mechanical seal, ensuring proper alignment and tightness.

• Reassemble the pump or reactor, ...read more

Temperature calibration of a thermometer

• Calibration involves comparing the thermometer readings to a known standard

• Adjustments are made to the thermometer if there are any discrepancies

• Calibration is important to ensure accurate and reliable temperature measurements

• Examples of standards used for calibration include NIST-traceable thermometers and ice-point method

Titrations are analytical techniques used to determine the concentration of a substance in a solution by reacting it with a known volume and concentration of another substance.

• Types of titrations include acid-base titrations, redox titrations, and complexometric titrations.

• Procedures involve adding a titrant (solution of known concentration) to the analyte (solution of unknown concentration) until the reaction is complete.

• Methods include using indicators to determine the endp...read more

Overhead rate for Inventory valuation is calculated by dividing total overhead costs by total direct labor hours. Inventory valuation methods include FIFO, LIFO, and weighted average. CAS 4 deals with depreciation accounting. CAS applicable in current company may vary. Good knowledge in MS Excel is essential. COP is the cost of producing goods, while COGS is the cost of goods sold.

• Calculate overhead rate by dividing total overhead costs by total direct labor hours

• Inventory va...read more

Analytical method validation involves testing and verifying the accuracy and reliability of a method for analyzing a sample.

• Define the purpose and scope of the method

• Select appropriate analytical parameters

• Conduct method development and optimization

• Perform method validation experiments

• Document and report results

• Repeat validation periodically

• Examples: HPLC, GC, titration, spectrophotometry

Reactions are chemical processes that involve the transformation of one or more substances into new substances.

• Combustion: a reaction between a fuel and an oxidant that produces heat and light (e.g. burning of wood)

• Acid-base: a reaction between an acid and a base that produces water and a salt (e.g. reaction between hydrochloric acid and sodium hydroxide)

• Redox: a reaction in which there is a transfer of electrons between reactants (e.g. rusting of iron)

• Polymerization: a react...read more

Calibration parameters are variables used to adjust or fine-tune a system or instrument to ensure accuracy and reliability.

• Calibration parameters are used to adjust or align measurements to a known standard.

• They are typically specific to the system or instrument being calibrated.

• Examples of calibration parameters include gain, offset, linearity, and sensitivity.

• Calibration parameters can be adjusted manually or automatically.

• Regular calibration is important to maintain the ac...read more

Choosing columns for analytical methods

• Consider the analyte properties and selectivity of the column

• Choose a column with appropriate dimensions and particle size

• Evaluate the compatibility of the column with the sample matrix

• Consider the cost and availability of the column

• Perform method validation to ensure column suitability

Validation parameters are criteria used to ensure that data or processes meet certain standards or requirements.

• Validation parameters can include accuracy, completeness, consistency, and timeliness.

• For example, in data entry, validation parameters may include checking for correct formatting, required fields, and valid values.

• In software development, validation parameters may include testing for functionality, usability, and security.

• Validation parameters can also be used in m...read more

Assay in drug substance is a test used to determine the potency or concentration of a drug in a sample.

• Assay is a quantitative analysis method used to measure the amount of a specific substance in a sample.

• It is commonly used in pharmaceutical industry to ensure the quality and consistency of drug products.

• Assay results are compared to a standard reference to determine the potency or concentration of the drug.

• Examples of assays include HPLC (High Performance Liquid Chromatogr...read more

Alcoa stands for Analytical Laboratory Control on Arrival, a process used in the pharmaceutical industry to ensure the quality of raw materials.

• Alcoa is a set of guidelines used to ensure data integrity in pharmaceutical manufacturing.

• It stands for Attributable, Legible, Contemporaneous, Original, and Accurate.

• Alcoa principles are used to ensure the reliability and accuracy of data in pharmaceutical testing and analysis.

• For example, ensuring that all data is attributable to a...read more

The question is unclear and lacks context. Please provide more information.

• The question needs to be more specific about what it means by 'companies changes'

• It would be helpful to know the industry or sector being referred to

• Without more information, it is impossible to provide an accurate answer

Method precision refers to the consistency of results obtained from the same method, while system precision refers to the consistency of results obtained from different methods or instruments.

• Method precision is important for ensuring the reliability of a single method or instrument.

• System precision is important for ensuring the comparability of results obtained from different methods or instruments.

• The difference between method precision and system precision can impact the a...read more

Assay formula is a specific calculation used to determine the concentration or purity of a substance in a sample.

• Assay formula typically involves measuring the amount of a specific compound or molecule in a sample.

• It may involve using a standard curve to determine the concentration of the substance.

• Assay formulas can vary depending on the type of assay being performed, such as ELISA or PCR.

• Examples include calculating the protein concentration in a sample using a Bradford ass...read more

Standard agreement formula is a legally binding document outlining terms and conditions agreed upon by parties involved.

• Include names and signatures of all parties involved

• Clearly outline the terms and conditions of the agreement

• Specify the duration of the agreement

• Include clauses for termination and dispute resolution

• Ensure the agreement is legally binding and enforceable

The Safety Triangle is a concept used in occupational safety to illustrate the three key elements of safety: engineering, education, and enforcement.

• The Safety Triangle emphasizes the importance of engineering controls, such as safety equipment and machinery safeguards, in preventing accidents.

• Education plays a crucial role in promoting safety awareness and providing training to employees on safe work practices.

• Enforcement involves implementing and enforcing safety policies, ...read more

I am responsible for ensuring the quality of products through analysis and testing.

• Performing quality control tests on raw materials, in-process samples, and finished products

• Analyzing data and identifying trends or deviations from standards

• Documenting test results and communicating findings to relevant stakeholders

• Troubleshooting issues and recommending corrective actions

• Ensuring compliance with regulatory requirements and quality standards

Safety refers to the measures taken to prevent accidents, injuries, and hazards in order to protect individuals and promote well-being.

• Safety involves identifying and assessing potential risks and hazards in the workplace or environment.

• It includes implementing preventive measures such as safety protocols, training programs, and safety equipment.

• Safety also involves promoting a safety culture and ensuring compliance with safety regulations and standards.

• Examples of safety mea...read more

LEL stands for Lower Explosive Limit and UEL stands for Upper Explosive Limit.

• LEL is the lowest concentration of a flammable substance in air that can ignite and sustain combustion.

• UEL is the highest concentration of a flammable substance in air that can ignite and sustain combustion.

• Concentrations below LEL are too lean to burn, while concentrations above UEL are too rich to burn.

• Knowing LEL and UEL helps in determining safe working conditions and preventing explosions.

• For e...read more