Senior QC Officer Interview Questions and Answers

Updated 15 Aug 2023

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Q1. 1:Which type of instruments you have handled ? 2: In Which software you have worked? 3: Questions asked abet HPLC , GC, KF,etc 4: How to calibration of instruments questions. 5: What is AMC?

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Answering questions related to instruments handling, software usage, calibration, and AMC.

Handled various instruments such as HPLC, GC, KF, etc.
Worked with software like Empower, Chromeleon, etc.
Calibration of instruments involves checking and adjusting the accuracy of the instrument using standard solutions.
AMC stands for Annual Maintenance Contract, which is a service agreement between the instrument manufacturer and the user for regular maintenance and repair of the instru...read more

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The pore size of filter paper used in filtration method varies depending on the type of filter paper.

The pore size can range from a few microns to several hundred microns.
Smaller pore sizes are used for fine filtration to remove smaller particles.
Larger pore sizes are used for faster filtration but may allow larger particles to pass through.
Common pore sizes for filter paper range from 0.2 to 10 microns.
Filter paper with a pore size of 0.45 microns is commonly used for microb...read more

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The microbial limit of raw water for bacteria and fungi is typically set at 100 CFU/mL for bacteria and 50 CFU/mL for fungi.

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The cup borer used for antibiotics assay as per BP is the 8 mm cup borer.

The cup borer used for antibiotics assay as per BP is the 8 mm cup borer.
It is specified in the British Pharmacopoeia (BP) that the 8 mm cup borer should be used for antibiotics assay.
Using the correct cup borer size is crucial for accurate and consistent results in antibiotics assay.

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Ans.

Bile tolerant gram negative bacteria can be tested quantitatively using selective media containing bile salts.

Use MacConkey agar with bile salts to selectively grow and differentiate bile tolerant gram negative bacteria.
Count the number of colonies that grow on the agar to quantify the bacteria present.
Perform a series of dilutions and plate counts to determine the concentration of bile tolerant gram negative bacteria in a sample.

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Phosphate buffer pH 7.4 is used for antibiotics assay of erythromycin.

Phosphate buffer pH 7.4 is commonly used for antibiotics assay of erythromycin
The buffer helps maintain a stable pH for accurate assay results
Other buffers like acetate buffer or citrate buffer may also be used depending on the specific assay requirements

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