Macleods Pharmaceuticals Research Associate Interview Questions, Process, and Tips for Experienced

Tailing factor is a measure of peak asymmetry in chromatography, indicating the presence of tailing or fronting.

• Tailing factor is calculated by dividing the distance from the peak apex to the leading edge of the peak by the distance from the peak apex to the trailing edge of the peak.

• A tailing factor of 1 indicates a symmetrical peak, while values greater than 1 indicate tailing and values less than 1 indicate fronting...read more

Method validation parameters ensure accuracy and reliability of analytical methods.

• Method validation parameters include specificity, accuracy, precision, linearity, range, limit of detection, and limit of quantification.

• Specificity ensures that the method measures only the analyte of interest.

• Accuracy measures how close the measured value is to the true value.

• Precision measures the reproducibility of the method.

• Lineari...read more

LOD and LOQ are the lowest detectable and quantifiable concentrations of an analyte, respectively.

• LOD is the lowest concentration of an analyte that can be detected with a given method.

• LOQ is the lowest concentration of an analyte that can be accurately quantified with a given method.

• LOD and LOQ are important parameters in analytical chemistry and are used to determine the sensitivity of an analytical method.

• For exampl...read more

fd is not a commonly used abbreviation or acronym in any specific field.

• There is no widely accepted definition for fd.

• It could potentially stand for a variety of things depending on the context.

• Without more information, it is impossible to provide a specific answer.

HPLC calibration involves preparing standard solutions, injecting them into the system, and adjusting parameters to ensure accurate and precise measurements.

• Prepare standard solutions of known concentration

• Inject the standard solutions into the HPLC system

• Adjust parameters such as flow rate, column temperature, and detector wavelength to optimize separation and detection

• Compare the retention times and peak areas of the...read more