Aurigene Oncology Limited Research Associate II Interview Questions and Answers

Q1. How to handle and quench pyrophoric chemical in reaction.
Ans. 
Pyrophoric chemicals can be handled and quenched by using inert gases, specialized containers, and proper disposal methods.
• Use inert gases such as nitrogen or argon to displace air and prevent ignition.

• Store and handle pyrophoric chemicals in specialized containers such as air-tight glass ampoules or sealed metal containers.

• Dispose of pyrophoric chemicals properly by contacting a hazardous waste disposal company.

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Q2. Name reactions based on palladium chemistry and copper chemistry
Ans. 
Palladium and copper chemistry are widely used in organic synthesis. Some important reactions include Suzuki coupling, Heck reaction, Sonogashira coupling, and Ullmann reaction.
• Suzuki coupling: cross-coupling reaction between an organoboron compound and an organic halide or triflate catalyzed by a palladium complex

• Heck reaction: coupling of an aryl or vinyl halide with an alkene in the presence of a palladium catalyst

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Q3. Different oxidising and reducing agent for ester reduction,cyano reduction, alchol oxidation
Ans. 
Different oxidising and reducing agents used for ester reduction, cyano reduction, and alcohol oxidation.
• Ester reduction: Lithium aluminum hydride (LiAlH4), sodium borohydride (NaBH4), diisobutylaluminum hydride (DIBAL-H)

• Cyano reduction: Lithium aluminum hydride (LiAlH4), sodium borohydride (NaBH4)

• Alcohol oxidation: Chromium trioxide (CrO3), potassium permanganate (KMnO4), Jones reagent (CrO3/H2SO4)
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Q4. Indole, oxazole and isoxazole synthesis route
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Q1. Tell me about yourself
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Q1. Based upon your Resume and basic of oranic chemistry as well as Name reactions
Ans. Name reaction done by you earlier and designing of experiments DOE is major task for SRS
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Q1. Can you relocate to noida?
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Q2. Discussion on early joining?
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Q1. Introduce yourself and why I'm hairing you
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Q1. Research work done in m.pharm
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Q1. Final selection is required
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Q1. Named reactions , functional froup interconversion, analytical data interpretations, retrosynthetic analysis, scheme design of target molecule.
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Q2. Nmr characterization, FG Interconversion, awareness of pyrophoric reagents.
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Q3. LCMS halogens peakspattern .
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Q4. Nmr data interpretation.
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Q5. Functional group intercinversion, retrosynthesis.
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Q6. C- C bond formation , C-N bond formation.
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Q7. Reaction mechanisms
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Q1. Self introduction and other
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Q2. Other questions and it
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Research reaction and CV according

Q1. Package discussion.
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Q2. Family discussion
Ans. Father and mother what's is doing.
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