Synthetic Chemistry - Scientist

Mandatory expectation for all roles as per Syngene safety guidelines

• Overall adherence to safe practices and procedures of oneself and the teams aligned.
• Contributing to development of procedures, practices and systems that ensure safe operations and compliance to company's integrity & quality standards.
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams, and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self
• Compliance to Syngene's quality standards at all times
• Hold self and their teams accountable for the achievement of safety goals.
• Govern and Review safety metrics from time to time.

Core Purpose of the Role:

Personnel handling this profile will be responsible for conducting reactions and delivering final compounds within a fast turnaround time, meeting the specific requirements of both the project and Syngene. The candidate should be capable of independently designing the synthetic scheme for any target and solve chemistry problems. He or she should ensure that the experimental observations are recorded contemporaneously and in compliance with the Electronic Laboratory Notebook (ELN) policies of the project and Syngene.

Role Accountabilities:

• Expected to design a synthetic scheme for any given target and to be proactive in identifying rate limiting steps along with the mitigation strategy.
• The candidate should be well versed in using literature search engines and predictive synthesis tools
• Perform synthetic chemistry reactions, reaction workups, purification of the compounds by column chromatography, crystallization, re-crystallization techniques, preparative TLC and operating lab equipments.
• Ensure that the samples generated during synthesis are given for analysis and record subsequent results obtained and update the supervisor / group leader on the progress of synthesis and ensure samples are packed appropriately for shipment
• Record the observations of experiment/reaction, results, utilization of resources and other activities related to the reaction in the laboratory or e-notebook following guidelines and in timely manner and ensure that the same is handled safely and confidentially.
• The candidate should be capable of meeting Syngene's productivity expectations (# of compounds/month, # of steps/month and productivity index of around 1.5) without compromising on safety and quality.
• The candidate should be capable of synthesizing the final compounds at a faster turnaround time.
• The candidate should have excellent analytical interpretation and purification skills.
• Ensure that they know the SDS of the chemicals they are handling and aware of emergency response procedures in case of accidental spillage, leakage or fire and ensure proper waste segregation as per EHS norms.
• Always follow EHS and quality system requirements in the workplace ensuring individual safety and lab safety.
• Attend all mandatory trainings and update training records as and when trainings are completed.
• Always ensure confidentiality.

Skills and Capabilities:

• Should have deeper knowledge with concepts of organic synthesis and reaction mechanisms.
• Should be capable of designing synthetic schemes and troubleshooting synthesis problems independently.
• Should be excellent in purification and analytical interpretation skills.
• Familiar with operations of relevant apparatus - instrument / equipment.

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status regarding public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities