Oligonucleotide - Senior Research Associate

Role & responsibilities

• Independently handling automated oligo synthesizer (K&A-H16/Mermade-192/ ÄKTA oligosynth)
• Synthesis of DNA, RNA, ASOs, and modified oligonucleotides, conjugation using different reactions (amide, click, S-S, etc)
• Method development for the purification (HPLC, IEX, SEC, PAGE) and characterization of the chemically modified and conjugated oligonucleotides by various analytical techniques (LCMS, MALDI, HRMS, etc.) and data interpretation.
• Hands-on experience in handling purification instruments HPLC, AKTA-Pure, etc.
• Excellent critical thinking, scientific skills, exposure to oligonucleotide discovery processes and current research trends
• Team player, with experience in planning and conducting scientific experiments, focusing on deliverables of the project right from initiation to end.

Preferred candidate profile

• Should be familiar with oligo-synthesis (nmol to µmol to mmol scale) by using solid phase synthesis & purification (RP-HPLC, IEX, PAGE, etc)
• Familiar with operations of relevant apparatus - instrument / equipment.
• It is mandatory for candidates to have a research background with expertise in Oligonucleotide Chemistry.