How to increase dissolution What is diluent,binder,lubrication,disintegrant and coating with examples

Question

Accepted Answer

To increase dissolution, one can use various techniques such as selecting appropriate diluents, binders, lubricants, disintegrants, and coatings.

Diluent: An inert substance added to a drug formulation to increase its bulk and aid in the dissolution process. Example: lactose.
Binder: A substance that helps in binding the ingredients of a tablet or capsule together. Example: hydroxypropyl cellulose.
Lubrication: The process of reducing friction between particles to enhance dissolution. Example: magnesium stearate.
Disintegrant: A substance that promotes the breakup of a tablet or capsule into smaller particles upon contact with water. Example: croscarmellose sodium.
Coating: A thin layer applied to tablets or capsules to protect the drug from degradation and control its release. Example: hydroxypropyl methylcellulose.

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