GVK Emergency Management and Research Institute Executive Interview Questions and Answers

Discrimination media in dissolution refers to the selective dissolution of certain components in a mixture.

• It occurs when certain components dissolve faster or slower than others due to differences in solubility or chemical properties.

• Examples include the dissolution of sugar in water, where sugar dissolves faster than other components like sand or salt.

• In pharmaceuticals, discrimination media can be used to test the d...read more

Peak purity is a measure of the homogeneity of a chromatographic peak and is calculated using spectral data.

• Peak purity is determined by comparing the spectral data of the peak at different wavelengths.

• A peak with high purity will have a consistent spectral pattern across all wavelengths.

• Peak purity can be calculated using software or manually by comparing the spectra.

• Peak purity is important in ensuring accurate quant...read more

System suitability criteria for RS and Assay method

• RS: resolution between critical pairs should be greater than 1.5

• Assay: accuracy, precision, linearity, range, specificity, LOD, LOQ

• Acceptance criteria should be predefined and met

• System suitability test should be performed before sample analysis

Linearity and accuracy are important measures in remote sensing. Linearity refers to the relationship between input and output values, while accuracy refers to the closeness of measured values to true values.

• Linearity measures the consistency of the relationship between input and output values

• Accuracy measures the closeness of measured values to true values

• Linearity and accuracy are important for ensuring reliable and ...read more

Specificity can be performed by measuring the ability of a test to correctly identify those without the condition.

• Specificity is a statistical measure that evaluates the accuracy of a test.

• It is calculated by dividing the number of true negatives by the sum of true negatives and false positives.

• A high specificity indicates that the test is good at identifying those without the condition.

• For example, a test for a rare d...read more

There are several types of columns in HPLC, including C18, C8, phenyl, and more. Column selection depends on the analyte and separation goal.

• Common types of HPLC columns include C18, C8, phenyl, and more

• Column selection depends on the analyte and separation goal

• C18 columns are commonly used for hydrophobic compounds

• Phenyl columns are useful for separating aromatic compounds

• C8 columns are a good alternative to C18 for s...read more

RI detector measures the refractive index of a sample to detect its presence and concentration.

• RI detector works by measuring the change in the angle of light as it passes through a sample with a different refractive index.

• The detector can be used in various industries such as pharmaceuticals, food and beverage, and environmental monitoring.

• RI detector is commonly used in high-performance liquid chromatography (HPLC) t...read more

Caffeine is used in HPLC calibration tests to determine the accuracy and precision of the instrument.

• Caffeine is a common standard used in HPLC calibration tests because it is readily available, stable, and has a well-defined retention time.

• The tests involve injecting a known amount of caffeine into the HPLC system and measuring its retention time and peak area.

• The results are compared to established reference values t...read more