What is mass balance and limit of it

Question

Accepted Answer

Mass balance is a principle used in various scientific disciplines to account for the mass of substances in a system.

Mass balance is based on the principle of conservation of mass, which states that mass cannot be created or destroyed, only transferred or transformed.
It involves tracking the inputs, outputs, and accumulation of mass within a system.
Mass balance equations are commonly used in environmental science, chemistry, and engineering.
For example, in environmental science, mass balance can be used to study the movement and fate of pollutants in ecosystems.
The limit of mass balance occurs when there is a significant loss or gain of mass that cannot be accounted for within the system.

Accepted Answer

Mass balance is the %assay loss of drug should be found in degradation of product.

The sum of amount loss in assay and amount of degradant impurity found should be equivalent to 100%

Limit of mass balance is 95% to 105%

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