Apitoria Pharma DPT.Manager Interview Questions and Answers

To prepare the QC laboratory for an audit, follow these steps:

• Ensure all equipment is calibrated and validated

• Review and update standard operating procedures (SOPs)

• Train laboratory personnel on audit procedures and expectations

• Perform internal audits to identify and address any non-compliance issues

• Organize and maintain documentation, including records of test results and equipment maintenance

• Implement a robust quality...read more

An OOS investigation is a process to determine the cause of an out-of-specification result in a product or process.

• OOS stands for Out-of-Specification.

• It involves a thorough investigation to identify the root cause of the deviation.

• The investigation may include reviewing manufacturing records, conducting laboratory tests, and analyzing data.

• One example of an OOS investigation is when a pharmaceutical product fails to m...read more

Incident management process involves identifying, responding to, and resolving incidents to minimize their impact on business operations.

• The process starts with incident identification, where incidents are reported or detected.

• Once an incident is identified, it is logged and categorized based on its severity and impact.

• A response team is then assigned to investigate and resolve the incident.

• During the investigation, th...read more

Calibration of HPLC involves adjusting and verifying the accuracy and precision of the instrument.

• Calibration ensures that the HPLC system is performing accurately and reliably.

• It involves adjusting parameters such as flow rate, detector wavelength, and injection volume.

• Calibration standards of known concentration are used to verify the accuracy of the system.

• Precision is assessed by analyzing replicate injections of a...read more

Validation is the process of checking if something meets certain criteria. Types of validation include data validation, form validation, and email validation.

• Validation is the process of ensuring that something meets specific requirements or standards.

• Data validation involves checking the accuracy, completeness, and consistency of data.

• Form validation ensures that user input in web forms is correct and meets specified ...read more

To fix the specification limit for an unknown impurity in an API, conduct thorough analysis and consider regulatory guidelines.

• Perform comprehensive analysis of the impurity to determine its identity, properties, and potential risks

• Refer to regulatory guidelines and industry standards to establish acceptable limits for impurities

• Consider the impact of the impurity on the quality, safety, and efficacy of the API

• Collabor...read more

Reaction scheme involves the conversion of functional groups and analysis of NMR values.

• Reaction scheme involves a series of chemical reactions to convert one functional group to another.

• NMR values are used to analyze the chemical environment of different atoms in a molecule.

• Examples of functional group conversions include alcohol to alkene, carboxylic acid to ester, etc.

Currently responsible for overseeing team performance, developing strategies, and ensuring project deadlines are met.

• Leading a team of 10 employees in project management

• Developing and implementing strategies to improve efficiency

• Monitoring progress and ensuring deadlines are met

• Collaborating with other departments to achieve company goals

Separation techniques are used in quality control to separate and analyze different components of a sample.

• Separation techniques are used to isolate and identify individual components in a mixture or sample.

• Common separation techniques include chromatography, distillation, filtration, and centrifugation.

• Chromatography separates components based on their different affinities for a stationary phase and a mobile phase.

• Dis...read more