Scientific Business Manager Interview Questions and Answers

ARBs block angiotensin II receptors, reducing vasoconstriction and aldosterone release. There are multiple generations of ARBs with varying selectivity and potency.

• ARBs work by blocking angiotensin II receptors, leading to vasodilation and decreased aldosterone release

• First generation ARBs include losartan and valsartan

• Second generation ARBs like olmesartan and telmisartan have increased selectivity and potency

• There are also combination ARB drugs like valsartan/sacubitril for...read more

Endoxifen is the active metabolite of tamoxifen, a drug used in the treatment of breast cancer.

• Endoxifen is formed through the metabolism of tamoxifen by the enzyme CYP2D6.

• It has a higher affinity for estrogen receptors compared to tamoxifen.

• Endoxifen inhibits the growth of estrogen receptor-positive breast cancer cells.

• It is considered to be the main contributor to the anti-cancer effects of tamoxifen.

Tamoxifen is a medication that is used to treat and prevent breast cancer by blocking the effects of estrogen in the breast tissue.

• Tamoxifen is a selective estrogen receptor modulator (SERM) that binds to estrogen receptors in breast cancer cells.

• It is commonly used in the treatment of hormone receptor-positive breast cancer.

• Tamoxifen can also be used to reduce the risk of breast cancer in women at high risk of developing the disease.

• Side effects of tamoxifen may include hot ...read more