Oligo Synthetic Chemist

Job title: Senior Research Associate

Job Location: Bangalore

About Syngene: Syngene ( www.syngeneintl.com ) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply.

At Syngene, Safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and sops, in letter and spirit

The mandatory expectation for all roles as per Syngene safety guidelines

• Overall adherence to safe practices and procedures of oneself and the teams aligned
• Contributing to the development of procedures, practices, and systems that ensure safe operations and compliance to the company s integrity & quality standards
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring the safety of self, teams, and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory training related to data integrity, health, and safety measures are completed on time by all members of the team including self
• Compliance to Syngene s quality standards at all times
• Hold self and their teams accountable for the achievement of safety goals
• Govern and Review safety metrics from time to time

Core Purpose of the Role:

• Personnel handling this profile will be responsible for performing reactions as per the requirement of the project. They are also responsible for documenting the observations in relevant notebooks. They are to follow instructions from the supervisor and work in a group (or individually) to accomplish the tasks in a timely and efficient manner

Role Accountabilities:

• Independently handling automated oligo synthesizer (K&A-H16/Mermade-192/ KTA oligosynth)
• Synthesis of DNA, RNA, ASOs, and modified oligonucleotides, conjugation using different reactions (amide, click, S-S, etc)
• Method development for the purification (HPLC, IEX, SEC, PAGE) and characterization of the chemically modified and conjugated oligonucleotides by various analytical techniques (LCMS, MALDI, HRMS, etc.) and data interpretation
• Hands-on experience in handling purification instruments HPLC, AKTA-Pure, etc
• Excellent critical thinking, scientific skills, exposure to oligonucleotide discovery processes and current research trends
• Team player, with experience in planning and conducting scientific experiments, focusing on deliverables of the project right from initiation to end
• Ensure that the samples generated during synthesis are given for analysis and record subsequent results obtained and update the supervisor / group leader on the progress of synthesis and ensure samples are packed appropriately for shipment
• Record the observations of experiment/reaction, results, utilization of resources and other activities related to the reaction in the laboratory or electronic lab notebook (ELN) following guidelines and in timely manner and ensure that the same is handled safely and confidentially.
• Ensure that the instrument / equipment is calibrated, undergone preventive maintenance, and are kept clean before use and in case of any breakdown, report to maintenance immediately
• Ensure that they know the MSDS of the chemicals they are handling and aware of emergency response procedures in case of accidental spillage, leakage or fire and ensure proper waste segregation as per EHS norms
• Always follow EHS and quality system requirements in the workplace ensuring individual safety and lab safety
• Attend all mandatory trainings and update training records as and when trainings are completed
• Always ensure confidentiality
• Flexible to work in shift

Specific requirements for this role

• Should be familiar with oligo-synthesis (nmol to mol to mmol scale) by using solid phase synthesis & purification (RP-HPLC, IEX, PAGE, etc)
• Familiar with operations of relevant apparatus - instrument / equipment.

Experience: 3-6years

Skills and Capabilities:

• Should have deeper knowledge with concepts of oligo synthesis and reaction mechanisms
• Candidate should be capable of solving synthetic problems independently
• Should be excellent in purification and analytical interpretation skills.
• Familiar with operations of relevant apparatus - instrument / equipment.

Education

• MSc (Chemistry / Biochemistry /Biotech) with 3 - 6 years of industrial experience

Equal Opportunity Employer: It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities