Research Asociate/ Sr. Research Associate

Educational qualifications

• Responsible for Bioanalysis using LC-MS/MS under GLP and non-GLP environment. Quantitation of small molecule using LC-MS/MS and can perform metabolite identification work on High resolution mass spectrometry.

Key Responsibilities

• Responsible for drug metabolism and pharmacokinetic support for discovery programs.
• Monitor Pharmacokinetics studies and support bioanalysis
• Providing pre-clinical ADME lead optimization support to small molecule Drug Discovery programs (Hit Identification to Clinical Candidate Selection) including Inflammation, Neuroscience, Metabolic Disorders and Anti-infective Research.
• Understand the Chemical Structure - ADME relationships and design apt strategies towards improving Drug like Properties of the New Chemical Entities.
• Understand the broader ADME requirements of various projects
• Conduct PK and PK/PD analysis through early pre- clinical development, and collaborate in PK/PD and efficacy study designs
• Design tailor made ADME protocols for various projects
• Collate the obtained results and prepare presentations for internal and external meetings
• Prediction of human pharmacokinetic properties from in vitro and in vivo data
• Managing PK and PK/PD analysis through early pre- clinical development, and collaborates in PK/PD and efficacy study design developing robust PK/PD models
• Prediction of human pharmacokinetic properties from in vitro and in vivo data in preclinical species.
• Method validations and analytical trouble shooting;
• Data generation, compilation, report preparation; Lab note book, record keeping; SOP writing
• Behavioral and Soft Skills
• Good attitude to work in a team and help other members in the team.