Harmonic Interview Questions and Answers

Pyrogen test is used to detect the presence of fever-causing substances in drugs or medical devices.

• Pyrogens are substances that can cause fever when introduced into the body.

• Rabbits are commonly used for pyrogen testing because they are sensitive to pyrogens.

• Other animals like guinea pigs and mice can also be used for pyrogen testing.

• Pyrogen testing is important to ensure the safety of drugs and medical devices before they are used on humans.

• The test involves injecting the s...read more

Disintegration is the breakdown of tablet into smaller particles while dissolution is the process of drug release from the tablet.

• Disintegration is a physical process while dissolution is a chemical process.

• Disintegration time is important for immediate release tablets while dissolution test is important for extended release tablets.

• Dissolution test helps to determine the rate and extent of drug release from the tablet.

• Dissolution test is important for quality control and to ...read more

Disintegration test is a measure of time taken for a tablet to break down into smaller particles.

• It is performed to ensure that the tablet will dissolve properly in the body.

• The tablet is placed in a disintegration apparatus and subjected to a specified force.

• The time taken for the tablet to disintegrate is recorded.

• The test is usually performed on six tablets from each batch.

• The USP sets standards for disintegration time for different types of tablets.

Different types of tablets include regular tablets, chewable tablets, effervescent tablets, and sublingual tablets.

• Regular tablets are the most common type and are swallowed whole.

• Chewable tablets are designed to be chewed before swallowing.

• Effervescent tablets dissolve in water to create a fizzy solution.

• Sublingual tablets are placed under the tongue and dissolve quickly.

• Other types of tablets include enteric-coated tablets, buccal tablets, and vaginal tablets.

Evaluation of injection involves assessing its effectiveness, safety, and potential side effects.

• Evaluation includes monitoring the patient's response to the injection

• Assessing the injection site for any adverse reactions

• Checking for any potential drug interactions

• Evaluating the dosage and frequency of the injection

• Examples include evaluating the effectiveness of insulin injections for diabetes management

Capsule size refers to the physical dimensions of a capsule, typically measured in millimeters.

• Capsule size is determined by the amount of active ingredient and fillers needed for the medication.

• Capsules can range in size from 000 (largest) to 5 (smallest).

• Larger capsules may be easier to swallow, but smaller capsules may be more convenient for patients to take.

• Capsule size can also affect the rate at which the medication is absorbed by the body.

• Capsule size is important for ...read more

Evaluation of tablets involves assessing their safety, efficacy, and quality.

• Tablets are evaluated through clinical trials to determine their safety and efficacy.

• Quality evaluation involves testing for factors such as dissolution rate, stability, and purity.

• Tablets may also be evaluated for bioavailability and pharmacokinetics.

• Evaluation is important to ensure that tablets are safe and effective for use in patients.

• Regulatory agencies such as the FDA require extensive evaluat...read more