What are the different problems in tablet coating and their troubleshooting.

Question

Accepted Answer

Tablet coating problems and troubleshooting

Uneven coating: may be due to improper tablet bed temperature or spray gun malfunction
Cracking or peeling: can be caused by excessive moisture in the tablet bed or inadequate drying time
Mottling: may occur due to uneven distribution of coating solution or improper tablet bed temperature
Orange peel effect: can be caused by high viscosity of coating solution or improper spray gun settings
Tablet sticking: may be due to inadequate lubrication or excessive tablet bed temperature
Color variation: can occur due to inconsistent coating solution concentration or improper mixing

Accepted Answer

twinning reason: Spray rate is too high, Less Gun - Bed distance, low pan speed, low inlet air temperature.

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