What is hplc and principle Difference between Disintegration and Dissolution Criteria of Dissolution Cu test and Assay test Alcohol plus Hplc troubleshooting

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Accepted Answer

Answering questions related to HPLC, disintegration, dissolution, Cu test, assay test, and HPLC troubleshooting.

HPLC stands for High Performance Liquid Chromatography and is used to separate, identify, and quantify components in a mixture.
Disintegration is the process of breaking down a tablet or capsule into smaller particles, while dissolution is the process of dissolving the drug substance in a solvent.
Criteria of dissolution include the amount of drug substance dissolved, the time it takes to dissolve, and the temperature and pH of the solvent.
Cu test is used to determine the presence of copper in a sample, while assay test is used to determine the potency or purity of a drug substance.
Alcohol plus is a term used to describe the addition of alcohol to a drug substance to improve its solubility.
HPLC troubleshooting involves identifying and resolving issues with the HPLC system, such as poor peak shape, baseline noise, or retention time shifts.

Accepted Answer

ALCOA and ALCOA+ are acronyms that refer to guidelines for data integrity and management in the pharmaceutical and biotechnology industries:

What is hplc and principle Difference between Disintegration and Dissolution Criteria of Dissolution Cu test and Assay test Alcohol plus Hplc troubleshooting

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