What is the different in GC And HPLC?

Question

Accepted Answer

GC and HPLC are both analytical techniques used to separate and analyze compounds, but they differ in their principles and applications.

GC separates compounds based on their volatility and affinity for the stationary phase, while HPLC separates compounds based on their polarity and affinity for the mobile and stationary phases.
GC is typically used for volatile and semi-volatile compounds, while HPLC is used for non-volatile and polar compounds.
GC requires a gaseous mobile phase, while HPLC uses a liquid mobile phase.
GC typically has faster analysis times and higher resolution, while HPLC has higher sensitivity and can handle larger sample volumes.
Both techniques have their own advantages and limitations, and the choice between them depends on the specific analytical needs and goals.

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